Dougherty, Edward S.
February 1965
Angiology;Feb1965, Vol. 16 Issue 2, p57
Academic Journal
1. Clinical evaluation of Pentrium, a new Librium/PETN combination, was conducted by means of a single-blind comparative study in 100 women patients with angina pectoris. 2. Employing comparable dosages, four agents�the patients' previous medication (a vasodilator), Librium alone, a placebo, and the test drug, Pentrium, rotated over four consecutive one-month periods, were compared as to their efficacy in lessening anginal attacks. The average daily nitroglycerin requirements (ADNR) of each subject served as the standard measure. 3. Results computed in comparative percentages showed that 76 patients required from 11 to 91 per cent less nitroglycerin during the month of Pentrium therapy than during their previous baseline (control) period on vasodilator, alone, whereas, 19 patients had increased ADNR with the test drug. Three patients showed insignificant increases or decreases (+ or -10 per cent) while two showed no change. 4. The ADNR per patient measured during Librium therapy, alone, versus the vasodilator, alone, showed comparable amounts of 1.7 and 1.5 tablets, respectively, while during placebo administration, all 100 patients' ADNR increased from over three to over five tablets per patient. The daily requirements of the group averaged less than one tablet (0.8) during Pentrium treatment. 5. The overall reduction in nitroglycerin requirements during Pentrium therapy, as compared with requirements during the vasodilator therapy alone, was found to be significant at the 0.001 level, on the basis of a nonparametric technique, the sign test.


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