Ebert, R. H.; Graham, R. C.
June 1966
Angiology;Jun1966, Vol. 17 Issue 6, p402
Academic Journal
The effects produced by the injection of histamine and serotonin in rabbit ear chambers are described. Histamine induced early arteriolar dilation and rapid venular blood flow. Early and transient rolling, sticking, and sometimes, emigration of leukocytes occurred with concentrations of histamine considerably higher than those required to cause increased vascular permeability in rabbit skin. The implications of these findings in regard to the possible role of histamine in the pathogenesis of inflammation are discussed. Serotonin administration was not associated with early inflammatory changes of the type seen after histamine. Early and relatively prolonged arteriolar dilation did occur. The most noteworthy effect was the formation of multiple venular platelet-leukocyte thromboemboli. The possible significance of this finding is discussed.


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