Whitt, John R.
February 1964
Angiology;Feb1964, Vol. 15 Issue 2, p82
Academic Journal
There is considerable evidence that the cerebral blood vessels constrict and dilate in response to a variety of stimuli. Some of those stimuli may be pathological, and the vascular responses may he of such frequency, severity, and localization as to produce symptoms and signs of neural deficit. When due to vasoconstriction, the condition may be termed �vasospasm,� has been demonstrated in experimental animals and in man, and is preventable by a variety of pharmacologic substances. Some of the newer compounds apparently relax vascular spasm without producing generalized hypotension. In the human, the EEG build-up response to forced hyperventilation is due to hypocapnie vasoconstriction. This response is preventable by papaverine, isoxsuprine and nylidrin in acute dosage, and to a much lesser extent by cyclandelate. The latter drug may require chronic administration to be effective. Minimum dosage and duration of drug effect may be determined by the method of the EEG hyperventilation response. Reports of therapeutic benefit by vasorelaxants in cerebral disorders have appeared with increasing frequency. Two recent reports of controlled trials indicate that isoxsuprine has some effect on chronic brain syndrome with cerebral arterio-sclerosis, and reduces the frequency of recurrent focal cerebral ischemic episodes. Additional controlled research is warranted, and wider employment of vasorelaxants in the management of cerebrovascular disease manifesting symptoms or signs possibly due to vasospasm.


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