TITLE

ISCHEMIC CEREBRAL LESIONS

AUTHOR(S)
Van Der Drift, J. H. A.
PUB. DATE
September 1961
SOURCE
Angiology;Sep1961, Vol. 12 Issue 9, p401
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Reviewing the applicability of drug therapy in patients with cerebral vascular insufficiency, the following resume is in order. When low systemic blood pressure is present, vasopressor drugs are indicated, particularly those which increase cardiac output. In patients with systemic hypertension, agents which lower blood pressure should be used with caution. Anticoagulants are of marked importance in patients with verebral basilar insufficiency in preventing a definite stroke. In patients with carotid insufficiency anticoagulants are probably of less value, especially if the transient attacks are due to systemic dynamic factors. If, however, an angiographically proved stenosis or occlusion of the internal carotid artery exists, use of anticoagulants in order to prevent embolization by fibrin platelet clots arising from mural thrombi must seriously be considered. Cyclandelate, a vasodilator which acts directly on the vascular smooth muscle, can be employed in an effort to prevent the recurrence of transient attacks or an acute stroke in the distribution area of the carotid artery. Cyclandelate may be of some importance in preventing ischemic attacks caused by vertebral basilar insufficiency if there exists a marked influence of hyperextension or rotation of the neck. Injection of papaverine or euphylline is indicated ia an impending stroke. It is suggested that, although vasospasm is of less importance than was supposed in earlier times, it may occur and influence cerebral blood flow in some cases.
ACCESSION #
16372461

 

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