Fremont, Rudolph E.
September 1961
Angiology;Sep1961, Vol. 12 Issue 9, p391
Academic Journal
1. The experimental and clinical evidence for the action of nitrates on the coronary, pulmonary and peripheral circulation has been reviewed. 2. Nitroglycerine as well as the long acting nitrates—erythrol tetrainitrate, (sublingual ETN, Cardilate) pentaerythrol tetranitrate (PETN, Peritrate) and the most recently introduced isosorbide dinitrate (ISDN, Isordil)—exert a distinct vasodilatory effect not only on the coronary arteries but also on other circulatory compartments. 3. The favorable effect of these nitrates on the anginal syndrome has been demonstrated by both careful symptomatic and objective evaluation utilizing exercise electrocardiograms and ballistocardiograms. The mechanism of action has, however, not yet been elucidated despite the employment of cardiac and coronary sinus catheterization.


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