TITLE

LONG-TERM ANTICOAGULANT THERAPY IN PRIVATE PRACTICE

AUTHOR(S)
Van Boven III, John
PUB. DATE
January 1964
SOURCE
Angiology;Jan1964, Vol. 15 Issue 1, p44
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. Between 1957 and 1961, 91 patients were started on anticoagulant therapy for thromboembolic disorders. Presently 58 patients are on warfarin sodium therapy. 2. The usual induction dose of this agent was 40 to 60 mg, and the usual maintenance dose was 7.5 mg daily. Elderly debilitated patients and all bed-ridden patients required smaller dosages, 3. Steroids, antibiotics, over indulgence in alcohol and prolonged exposure to heat and sunlight adversely affect good anticoagulant control, 4. Incidence of recurrent thrombosis in well-controlled patients on long-term therapy was 12.3 per cent. Incidence of recurrent thrombosis in short-term patients was 47 per cent. 5. The combined mortality rate in all anticoagulated patients was 20.2 per cent. Mortality rate for short-term anticoagulant therapy was 47 per cent. Mortality rate for long-term patients was 12.3 per cent. 6. Overall incidence of side effects was 21 per cent. However, only seven patients (7.7 per cent) had major bleedings; three of these patients had concomitant carcinoma; three had bleeding duodenal ulcers, and one had muscle hemorrhage associated with institution of phenylbutazone.
ACCESSION #
16372446

 

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