Decreased Venous Distensibility in Essential Hypertension: Lack of Systemic Hemodynamic Correlates

Simon, Geza; Franciosa, Joseph A.; Cohn, Jay N.
March 1979
Angiology;Mar1979, Vol. 30 Issue 3, p147
Academic Journal
Venous distensibility in essential hypertension has been reported to be unchanged or decreased; its pathophysiologic role is uncertain. In 27 male hypertensive patients and 21 normotensive control subjects, forearm venous distensibility and capillary filtration rate at 30 cm of H2O distending pressure were measured by strain gauge plethysmography. Plasma renin activity (PRA), plasma volume (PV) by the Evans blue dye dilution technique, mean arterial pressure (MAP) by cuff, and cardiac output (CO) by the CO2 rebreathing method were also measured. Compared to values in normotensive control subjects, forearm venous distensibility in hypertensive subjects was decreased (P < 0.05); the forearm venous pressure-volume curves (deflation phase) were shifted in the direction of the pressure axis (P < 0.02); and the capillary filtration rate was increased (P < 0.05). Venous distensibility changes in hypertensive subjects were unrelated to PRA, MAP, PV, CO, stroke volume, and total peripheral resistance. These findings confirm previous reports of decreased venous distensibility in hypertension and provide direct evidence for increased capillary filtration rate. In view of the lack of significant correlation between venous distensibility and the measured hemodynamic parameters, a pathophysiologic role for venous distensibility in hypertension could not be established.


Related Articles

  • Hypertension -- Noninvasive Testing.  // Current Medical Literature: Nephrology & Hypertension;2006, Vol. 12 Issue 4, p132 

    The article presents an abstract of the research "How long shall the patient rest before clinic blood pressure measurement?," by C. Sala and colleagues, published in the 2006 issue of the "American Journal of Hypertension." In the study, researchers monitored the changes in the arterial blood...

  • Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay. Whinnett, Z. I.; Davies, J. E. R.; Willson, K.; Manisty, C. H.; Chow, A. W.; Foale, R. A.; Davies, D. Wyn; Hughes, A. D.; Mayet, J.; Francis, D. P. // Heart;Nov2006, Vol. 92 Issue 11, p1628 

    Objective: To assess the haemodynamic effect of simultaneously adjusting atrioventricular (AV) and interventricular (VY) delays. Method: 35 different combinations of AV and W delay were tested by using digital photoplethysmography (Finometer) with repeated alternations to measure relative change...

  • Marily Rhudy to receive Jacob W. Miller Award.  // Pharmacy Today;Mar2006, Vol. 12 Issue 3, p24 

    The article reports that a study of community pharmacy-based hypertension interventions manifests that pharmacists can do much to help patients control their blood pressure. The large number of patients attended in the Hypertension Outcomes through blood pressure Monitoring and Evaluation by...

  • Measuring blood pressure at home is valuable.  // Journal of Family Practice;Dec2005, Vol. 54 Issue 12, p1031 

    The article investigates whether ambulatory blood pressure examination results are more predictive than in-office measurements of cardiovascular events. It included 1332 people older than 40 years who lived in the same town in Japan. Blood pressure of these people were measured twice in one...

  • under 40? a quick test tells if high blood pressure awaits you. Steinmehl, Eric; Martin, Adam // Health (Time Inc. Health);Mar2004, Vol. 18 Issue 2, p69 

    Suggests a way to detect the risk of high blood pressure. Percent chance of people whose pressure rose at least five points after standing to develop hypertension; Reason that the method suggested would not work for people over 40.

  • Easing the Pressure: The Ins and Outs of Hypertension.  // Nutrition Health Review: The Consumer's Medical Journal;2006, Issue 96, p2 

    The article focuses on hypertension. Hypertension is diagnosed when systolic blood pressure is greater than 140 millimeters of mercury (MM HG) and diastolic pressure is greater than 90 mmHg. Hypertension is a sign that the heart is working harder than it should have in order to keep the blood...

  • Acute effects of renin-angiotensin system blockade on arterial function in hypertensive patients. Aznaouridis, K. A.; Stamatelopoulos, K. S.; Karatzis, E. N.; Protogerou, A. D.; Papamichael, C. M.; Lekakis, J. P. // Journal of Human Hypertension;Aug2007, Vol. 21 Issue 8, p654 

    The acute effects of the renin-angiotensin system (RAS) blockers may be important in some clinical settings. To assess the acute impact of such drugs on arterial function, we studied the effects of captopril 25 mg, quinapril 20 mg and telmisartan 80 mg on 100 hypertensive patients, according to...

  • Treatment of hypertensive emergencies: blood pressure cosmetics or outcome evidence? Messerli, F. H.; Eslava, D. J. // Journal of Human Hypertension;Sep2008, Vol. 22 Issue 9, p585 

    The article reports that hypertensive emergencies occur when high blood pressure is related with the presence of acute end-organ damage that such of hypertensive encephalopathy. It discusses that there are controversies as to when and which antihypertensive drugs to use in contributed given...

  • Using Plasma Renin (PRA) Testing to Design Follow-Up Drug Treatment Strategies in Hypertensive Patients Already Taking Antirenin System Drugs. Sealey, Jean E.; Laragh, John H. // American Journal of Hypertension;Sep2009, Vol. 22 Issue 9, p950 

    The article presents a commentary on the study about using plasma renin (PRA) testing to design drug treatment strategies in hypertensive patients. According to the authors, the information provided by the test can be used to determine whether the patient is more likely to respond to a...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics