Horn, Leif; Malm, Ole J.
May 1964
Angiology;May1964, Vol. 15 Issue 5, p215
Academic Journal
Pretreatment with large doses of cortisone increased the mortality from thermal injury. Adrenalectomy increased the susceptibility to a rapid fatal outcome from burns. Implantation of deoxycorticosterone acetate pellets did not restore the tolerance of the adrenalectomized rats to normal. Animals treated with pharmacodynamic doses of insulin survived significantly longer than the controls but did not show an increase in permanent survival from lethal burns. Elevation of the epinephrine threshold in the mesentery was observed in the insulin treated unburned rat in a period of time corresponding to the peak mortality in the burned animal pretreated in identical manner. The results are discussed in relation to other work and three factors were considered to explain the observed changes in tolerance to extensive thermal injury. These were adrenocortical secretory capacity, catecholamine content of tissue and vascular responsiveness as conditioned by the general metabolic status of the animal. The data re-emphasize the importance of hormonal adaptation in relation to nonspecific tolerance to trauma.


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