TITLE

THE USE OF TRIPARANOL AND SODIUM DEXTROTHYROXINE TO LOWER SERUM CHOLESTEROL

AUTHOR(S)
Goyette, Edwin M.; Saad, Atif
PUB. DATE
February 1962
SOURCE
Angiology;Feb1962, Vol. 13 Issue 2, p89
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Triparanol in a daily dose of 250 mg lowered the serum cholesterol level in 102 of 121 patients by an average of 68 mg per cent. The average percentage drop was 19.1 per cent. Nineteen patients showed a rise which averaged 45 mg per cent, while the average percentage increase was 14 per cent. About 10 per cent showed unpleasant side effects. Sodium dextrothyroxine in a daily dose of 4 mg lowered the serum cholesterol level in 84 of 116 patients by an average of 68 mg per cent. The average percentage drop was 19.3 per cent. The magnitude of the drop was very similar to that observed with triparanol, side effects were less common with sodium dextrothyroxine. A combination of both drugs simultaneously after a trial with either one or both ot the 2 agents produced a fall in the serum cholesterol level in 37 of 54 patients. The average drop was 56.7 mg per cent, an average percentage drop of 17.2 per cent of the pretreatment level. Some patients failed to respond to triparanol but did respond to sodium dextrothyroxine. Similar results were observed in patients started on sodium dextrothyroxine, whose therapy was later changed to triparanol. A combination of both drugs simultaneously seems indicated in patients whose serum cholesterol level is still elevated after a trial with either or both drugs alone. There was no evidence that lowering the serum cholesterol level had any beneficial effect on the ischemic heart disease which was present in many patients.
ACCESSION #
16371436

 

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