TITLE

THE EFFECT OF DEXTROTHYROXINE ON THE DISAPPEARANCE FROM THE BLOOD OF C14-LABELED CHOLESTEROL A PRELIMINARY REPORT

AUTHOR(S)
Rabinowitz, Joseph L.; Rodman, Theodore; Smolinsky, Thelma L.
PUB. DATE
February 1962
SOURCE
Angiology;Feb1962, Vol. 13 Issue 2, p81
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
During a 25-day period when 8 mg dextro-thyroxine was given daily to patients, the serum was cleared of C14-labeled cholesterol 2 to 3 times as fast, and radioactive CO2 was detected in the expired air in greatly increased quantities, while the total serum cholesterol was reduced from a maximum lowering of 66 per cent and a minimum lowering of 34 per cent when compared to baseline studies performed in the same patients before the administration of dextrothyroxine. A patient also on 8 mg daily of dextrothyroxine showed total and radioactive cholesterol clearance 2 to 3 times faster than before treatment. The data suggest that dextrothyroxine markedly accelerates the breakdown of body cholesterol.
ACCESSION #
16371322

 

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