Cohen, Burton M.
February 1962
Angiology;Feb1962, Vol. 13 Issue 2, p69
Academic Journal
Sodium dextrothyroxine, the sodium salt of the dextrorotatory isomer of thyroxine, was administered in daily oral doses ranging from 4 to 8 mg to 30 patients with hypercholesterolemic states for 52 weeks. A drop in serum cholesterol values was recorded in every patient, and averaged a reduction of 32.3 per cent from pretreatment levels for the group as a whole. The most pronounced effects occurred in patients with the higher control cholesterol concentrations. This reduction in blood cholesterol elevation was achieved in patients with hypothyroidism, idiopathic hypercholesterolemia, and cardiovascular diseases, with and without diabetes mellitus. We have not observed escape from sodium dextrothyroxine control, nor have true ‘toxic’ effects been encountered. A marked rise in serum protein-bound iodine values occurred without evidences of hypermetabolism. Improvement in the symptomatic status of patients with angina pectoris unaccompanied by deterioration in the electrocardiogram or the state of cardiac compensation suggests the usefulness of sodium dextrothyroxine in patients with hypercholesterolemia complicating coronary artery disease.


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