TITLE

ANTIHYPERTENSIVE THERAPY WITH ORAL DIURETICS

AUTHOR(S)
Orvis, Harold H.; Epstein, Jerome H.; Kessler, Susan; Thomas, Raymond E.; Tamagna, Irene G.
PUB. DATE
July 1964
SOURCE
Angiology;Jul1964, Vol. 15 Issue 7, p305
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. Eight patients have been studied to evaluate antihypertensive therapy employing fixed doses of the oral diuretic compounds bendroflumethiazide and chlorothiazide singly and the former in combination with guanethidine. A significant reduction in mean diastolic blood pressure resulted with each treatment when compared to three control (placebo) periods. However, none of the mean treatment blood pressures differed significantly from each other. One of these eight patients experienced episodes of clinical gout during treatment with each of the diuretics. 2. Eight patients received bendroflumethiazide, 7.5 mg daily for 8 months. Although the mean blood pressures for the group indicated a sustained hypotensive effect, two patients appeared to lose their initial pressure effect, whereas two patients manifested a progression of pressure reduction in the ensuing months. 3. Eight patients received chlorothiazide, 1 gm daily for 8 months, and seven of the eight patients manifested a sustained hypotensive effect through the therapeutic period. 4. Twelve of the patients treated with the oral diuretics for 8 months manifested a rise in blood urea nitrogen averaging 4.4 mg per cent. All 16 patients demonstrated a rise in serum uric acid which subsequently lessened in 4 patients given 3 gm of potassium chloride daily. About one-half of the subjects showed a drop in serum potassium during therapy, but supplemental oral potassium administration was probably unnecessary in each instance. 5. In this study there were essentially no distinguishing features in the results of therapy attributable to difference between the two thiazide diuretics.
ACCESSION #
16371028

 

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