Orvis, Harold H.; Epstein, Jerome H.; Kessler, Susan; Thomas, Raymond E.; Tamagna, Irene G.
July 1964
Angiology;Jul1964, Vol. 15 Issue 7, p305
Academic Journal
1. Eight patients have been studied to evaluate antihypertensive therapy employing fixed doses of the oral diuretic compounds bendroflumethiazide and chlorothiazide singly and the former in combination with guanethidine. A significant reduction in mean diastolic blood pressure resulted with each treatment when compared to three control (placebo) periods. However, none of the mean treatment blood pressures differed significantly from each other. One of these eight patients experienced episodes of clinical gout during treatment with each of the diuretics. 2. Eight patients received bendroflumethiazide, 7.5 mg daily for 8 months. Although the mean blood pressures for the group indicated a sustained hypotensive effect, two patients appeared to lose their initial pressure effect, whereas two patients manifested a progression of pressure reduction in the ensuing months. 3. Eight patients received chlorothiazide, 1 gm daily for 8 months, and seven of the eight patients manifested a sustained hypotensive effect through the therapeutic period. 4. Twelve of the patients treated with the oral diuretics for 8 months manifested a rise in blood urea nitrogen averaging 4.4 mg per cent. All 16 patients demonstrated a rise in serum uric acid which subsequently lessened in 4 patients given 3 gm of potassium chloride daily. About one-half of the subjects showed a drop in serum potassium during therapy, but supplemental oral potassium administration was probably unnecessary in each instance. 5. In this study there were essentially no distinguishing features in the results of therapy attributable to difference between the two thiazide diuretics.


Related Articles

  • Rilmenidine effect on BF relates to improved QOL.  // PharmacoEconomics & Outcomes News;8/27/2005, Issue 485, p13 

    Discusses research being done on the effect of rilmenidine hypotensive agent on blood pressure and quality of life. Reference to a study by K. Kawecja-Jaszcz and colleagues, published in the June 2005 issue of the "Journal of Hypertension"; Link between rilmenidine and low blood pressure.

  • triamterene.  // Royal Society of Medicine: Medicines;2002, p545 

    This article presents information on triamterene which is a mild diuretic of the potassium-sparing type and so causes the retention of potassium. It can be used to treat oedema, as an antihypertensive. Administration is oral. Side-effects of the drug include gastrointestinal upsets, skin...

  • Antihypertensives. Cranwell-Bruce, Lisa A. // MEDSURG Nursing;Oct2008, Vol. 17 Issue 5, p337 

    The article examines different classes of drugs which are used in treating hypertension as well as their side effects. It offers considerations on the drugs' pharmacotherapeutics and pharmacodynamics effect as well as considerations about hypertension, which is defined as the constant increased...

  • Treatment for two types of hypertension.  // Clinical Advisor;Jan2014, Vol. 17 Issue 1, p36 

    The article evaluates the Adempas tablets for hypertension treatment from Bayer HealthCare Co. Ltd.

  • Pharmacological Evidence of Hypotensive Activity of Somina (Herbal drug) in Normotensive Rats. Azmat, A.; Ahmed, M. // Tropical Journal of Pharmaceutical Research;Nov2014, Vol. 13 Issue 11, p1863 

    Purpose: To evaluate the effects of somina (herbal drug) on the arterial blood pressure. Methods: Hypotensive activity was studied in pentothal sodium-anesthetized normotensive albino rats at various doses of somina (5, 10, 15, 20 and 35 mg/kg). The drugs were administered intravenously and...

  • Hypertension in renal transplantation. Olmer, Michel; Noordally, Réchard; Berland, Yvon; Casanova, Paul; Coulange, Christian; Rampal, Marius // Kidney International Supplement;Sep1988, Issue 25, p129 

    Reports on the role of hypertension as a frequent complication in renal transplantation within 3 to 6 months prior to the operation. Principal mechanisms suggested to explain increased blood pressure; Factors involved in determining the prevalence of hypertension after renal transplantation;...

  • Minoxidil in the Treatment of Refractory Hypertension. Rosenthal, Talma; Swartz, Jacob; Teicher, Avishai; Boichis, Hayim // Angiology;Feb1980, Vol. 31 Issue 2, p109 

    Minoxidil, a powerful vasodilator, is a very effective antihypertensive drug. It was used to treat 22 patients, most of whom were refractory to conventional antihypertensive medication. There was a swift and definite drop of blood pressure in all cases. In 7 patients with renal disease, renal...

  • Ramipril/felodipine extended-release fixed-dose combination: a guide to its use in essential hypertension.  // Drugs & Therapy Perspectives;Sep2007, Vol. 23 Issue 9, p1 

    The article offers information on the use of ramipiril/felodipine extended release (ER) fixed dose combination to control hypertension. Ramipiril and felodipine are antihypertensive agents belonging to different classes, the former is an ACE inhibitor while the latter is a calcium channel...

  • Adverse events of blood-pressure-lowering drugs: evidence of high incidence in a clinical setting. Gonçalves, Carla B. C.; Moreira, Leila B.; Gus, Miguel; Fuchs, Flávio D. // European Journal of Clinical Pharmacology;Oct2007, Vol. 63 Issue 10, p973 

    Our primary objective was to determine the incidence of AEs of antihypertensive drugs in a cohort of outpatients attending a specialized clinic. The secondary objectives were to determine the incidence of AEs by classes of blood-pressure-lowering drugs used in monotherapy and to identify risk...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics