Gould, William L.
March 1962
Angiology;Mar1962, Vol. 13 Issue 3, p129
Academic Journal
The basic concept of treating the aging process with the opposite sex hormones, which I originated in 1939 and reaffirmed in 1957, has been corroborated in principle by many independent investigators. The new concept of heterosexual hormone therapy provides encouraging results in the treatment of angina pectoris and coronary sclerosis. The serious side effects and hazards of the homologous sex hormones are so common as to preclude their use in cardiology. Fortification of chorionic gonadotropin and testosterone with thiamine hydrochloride (neurotropic) and L(+) glutamic acid (cerebrotropic) greatly increases their therapeutic effectiveness and permits the use of these hormones in reduced dosage. The reversible nature of early atherosclerotic lesions should encourage us to adopt a new therapeutic approach to aging and begin the treatment of incipient arteriosclerosis at a relatively early age. Angina pectoris, coronary sclerosis and cerebral arteriosclerosis in elderly men have responded satisfactorily to treatment with fortified chorionic gonadotropin. In women, fortified testosterone has also proved effective. Heterosexual hormone therapy is more effective than the use of homologous sex hormones and also free from their side effects and potential carcibogenicity. Therapeutic results on stale race horses and old and debilitated dogs and castrated male cats are comparable to those observed in human patients.


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