TITLE

A QUANTITATIVE METHOD FOR SCREENING DRUGS OF VALUE IN OCCLUSIVE VASCULAR DISEASE

AUTHOR(S)
Bevan, John A.; Postman, I. Marshall
PUB. DATE
March 1962
SOURCE
Angiology;Mar1962, Vol. 13 Issue 3, p104
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A method is presented whereby the ability of a drug to improve the collateral blood flow when the femoral artery is obstructed may lie quantitatively measured under controlled conditions in the mouse. Twenty-four hours after surgical ligation of one femoral artery, Cr51-tagged mouse erythrocytes are injected intravenously. Three minute's later both feet are amputated and their radioactivity measured. It is considered that the count of the foot from the unligated limb is a measurement of the volume of blood in the foot. The count of the foot from the ligated limb is a measurement of the collateral blood flow. Tolazoline and, to a greater degree, nylidrin, significantly decrease the radioactive counts of both feet.
ACCESSION #
16370960

 

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