TITLE

CLINICAL EVALUATION OF PROTOVERATRINE A USED ALONE AND IN COMBINATION WITH DIURETIC AGENTS

AUTHOR(S)
Kert, Morley J.; Roth, Samuel L.; Mailman, Richard H.; Dashe, Alfred M.; Avedon, Melvin
PUB. DATE
April 1962
SOURCE
Angiology;Apr1962, Vol. 13 Issue 4, p180
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on pharmacology of the drug protoveratrine a used alone and in combination with diuretic agents. These alkaloids exerts their hypotensive effects via the chemoreceptors in the heart, great vessels and carotid sinuses, apparently affecting vagal depressor reflexes as well as otherwise inhibiting peripheral vasoconstriction by central action. Parenteral veratrum will rapidly and uniformly cause lowering of elevated blood pressure. Unfortunately, oral administration of mixtures of veratrum alkaloids or of the pure refined alkaloids have no such uniformity.
ACCESSION #
16370914

 

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