Dintenfass, Leopold
August 1964
Angiology;Aug1964, Vol. 15 Issue 8, p333
Academic Journal
The flow and deformation properties of blood and vascular systems are most often neglected in the consideration of thrombosis and atherosclerosis. It is possible to show that a great difference exists between the blood of normal donors and the blood of patients suffering from venous thrombosis and coronary occlusion. The clotting of blood is shown to depend on the velocity gradient at which such clotting takes place. Aggregation of red cells seems to be a factor of importance to thrombosis. This aggregation is indicated by an excessively high thixotropy. Rheologic parameters such as viscosity, thixotropy, turbulence, velocity profile, velocity gradient, smoothness and roughness of the endothelial lining and viscoelasticity of the vessel walls are shown to be relevant to the stability of circulation and to the formation of thrombosis and atherosclerosis. An attempt is made to accommodate the present theories of thrombosis and atherosclerosis within a larger framework of physical and physicochemical interrelationships. It is indicated that the sequence of events in the cardiovascular disorders is not necessarily unidirectional find that the alternative pathways and feedbacks are available. It is suggested that any theory intending to a solution for thrombosis and atherosclerosis has to take into account not only the biochemical and histologic aspects, but also it has to take into account the rheologic parameters.


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