TITLE

RE-EVALUATION OF MYOCARDIAL BLOOD FLOW WITH MODIFIED RADIOISOTOPE TECHNIQUE

AUTHOR(S)
Johnson, Phillip C.; Horton, Granville; Driscoll, Theda B.
PUB. DATE
October 1962
SOURCE
Angiology;Oct1962, Vol. 13 Issue 10, p481
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. A modified radioisotope technique for estimating myocardial blood flow and cardiac output is briefly described. 2. A double-blind study is described in detail in which the above method was used for estimating myocardial blood flow and cardiac output after the administration of a placebo, two dosage forms of pentaerythritol tetranitrate, and various amounts of beverages containing varying percentages of alcohol. 3. Results (table 1) obtained with this method indicate that both dosage forms of pentaerythritol tetranitrate (Peritrate, 20-mg tablets and 80-mg sustained-action tablets) produced increases in mean myocardial blood flow at 2 and 4 hr. after the last dose that were statistically significant when compared to the effects of the placebo. Neither regimen caused changes in mean cardiac output that were statistically significant from control values. However, statistically significant differences were noted among the individual cardiac outputs of certain patients. 4. The sustained-action dosage form of pentaerythritol tetranitrate (Peritrate SA) increased myocardial blood flow for periods up to 10 hr. (table 2); statistically significant increases occurred up to and including 8 hr. No statistically significant changes in mean cardiac output occurred at any time after the administration of this dosage form of the drug. 5. When the method reported herein was used to estimate myocardial blood flow and cardiac output in patients receiving varying amounts of alcohol, considerable variability in onset of action and a tendency to decrease myocardial blood flow was noted (tables 3 and 4). These findings suggest that alcohol, as contained in the beverages used in this study, does not produce a constant effect on coronary circulation. 6. Results obtained in the present series of experiments are discussed and compared with previously reported results, as well as with certain published clinical data.
ACCESSION #
16370168

 

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