Whittier, John R.; Dhrymiotis, Andreas D.
July 1962
Angiology;Jul1962, Vol. 13 Issue 7, p324
Academic Journal
In 20 elderly female patients with diagnosis of chronic brain syndrome with cerebral arteriosclerosis with psychotic reaction, and in 20 young patients (age 35 or below) with diagnosis of schizophrenic reaction, the effect of hyperventilation on the electroencephalogram 10 min. after injection of saline and of 10 mg of isoxsuprine hydrochloride (intramuscularly) was observed. In eight elderly and nine young patients (42.5 per cent), abnormal slow waves (&delta and θ) were seen in electroencephalogram after initial hyperventilation and after hyperventilation following intramuscular injection of isotonic saline solution. Hyperventilation 10 min. after the intramuscular injection of isoxsuprine showed no abnormal slow waves in all eight elderly patients and in six young patients (82.5 per cent); in two young patients &delta- and θ-waves appeared, but less frequently, and in the remaining one patient, the appearance of slow waves was identical with those seen before the injection of isoxsuprine. It is concluded (1) that the observations confirm prior reports that cerebral vasoconstriction is accompanied by slowing of the electroencephalogram, and (2) that this vasoconstriction can be prevented by a vasodilator, isoxsuprine hydrochloride.


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