TITLE

THE EFFECT OF DEXTROTHYROXINE ON THE DISAPPEARANCE FROM THE BLOOD OF C14-LABELED CHOLESTEROL

AUTHOR(S)
Rabinowitz, Joseph L.; Rodman, Theodore; Smolinsky, Thelma L.
PUB. DATE
July 1962
SOURCE
Angiology;Jul1962, Vol. 13 Issue 7, p319
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
During a 25-day period when 8 mg of dextrothyroxine were given daily to three patients, the serum was cleared of C14-labeled cholesterol 2 to 3 times as fast as normal, and radioactive CO2 was detected in the expired air in greatly increased quantities, whereas the total serum cholesterol was reduced by a maximal lowering of 66 per cent and a minimal lowering of 34 per cent when compared with base line studies performed in the same patients before the administration of dextrothyroxine. A fourth patient, also on 8 mg daily of dextrothyroxine, showed total and radioactive cholesterol clearance 2 to 3 times faster than before treatment. The data suggest that dextrothyroxine markedly accelerates the breakdown of body cholesterol.
ACCESSION #
16369997

 

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