Jacoby, Hans
October 1964
Angiology;Oct1964, Vol. 15 Issue 10, p454
Academic Journal
Before present research on the pathogenesis of the gastroduodenal ulcer we investigated with our vital microscopic method the influence of arterial obstruction on the affected tissues. We found that in such tissues which are more or less cut off from the circulation, vasoactive metabolic substances accumulate and spill over into the circulating blood, The effects of such substances on the vessels and their microcirculation were studied with our vital microscopic method at the mucous membrane of the lip. The effects were seen as specific vascular and circulatory alterations which serve as a compensatory mechanism by increasing the capillary surface and by retarding the blood flow for a better exchange of nutritive materials at the blood tissue border. A full description of these alterations and our method is given. In gastroduodenal ulcer patients, we saw the same compensatory specific alterations of the microvessels and of the microcirculation as we saw in the patients with arterial obstruction. Thus we concluded that the principal etiology of the ulcer disease is also peripheral circulatory deficiency and is due to recurrent functional, or else, to permanent, organic arterial obstruction. In either case, we see the very narrow precapillary arterial sections of the terminal vascular bed with poor blood supply as a common feature of all ulcer patients. This fact explains the pathogenesis of the gastroduodenal ulcer as a peripheral circulatory deficiency disease.


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