Warner, Nancy E.; Bunnag, Sirotma; Bunnag, Srichitra C.; Bennington, James L.
October 1964
Angiology;Oct1964, Vol. 15 Issue 10, p440
Academic Journal
An experimental study of Escherichia coli endotoxemia was made in mice to correlate the microvascular reactions of the islets of Langerhans with levels of blood glucose. Following intravenous injection of endotoxin in an LD50 or more, intravascular clumping of blood cells was observed. Constriction of insular arterioles and venules, with alternating rapid and slow flow, was predominant at first but was succeeded by persistent dilation and slow flow. The vasomotor changes were especially prominent in the venules. The microvascular reactions were accelerated and more severe in mice receiving the lethal dose. In addition, the blood flow in the islets stopped intermittently for protracted periods in the terminal stages after lethal dose. The fluctuations in blood glucose suggest that abnormal insular function may accompany the abnormal vascular reactions in endotoxemia, since the phase of constriction is accompanied by a hyperglycemic peak, whereas the phase of dilation is accompanied by hypoglycemia. The implications of these findings in human bacteremic shock due to Gran-negative enteric bacilli, a syndrome which has assumed increasing importance in recent years, are discussed.


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