van Buchem, F. S. P.; Drion, E. F.
September 1964
Angiology;Sep1964, Vol. 15 Issue 9, p424
Academic Journal
A prospective study of 908 men, 40 to 60 years of age, showed that before myocardial infarction, angina pectoris or intermittent claudication developed the serum-cholesterol level was in 85 per cent of the cases 250 mg per cent or more. In the whole group 33 per cent of the men had a serum cholesterol level of 250 mg per cent or more. Before conduction disturbances and auricular fibrillation became manifest the serum cholesterol level was significantly higher than in cases who showed these lesions already by the beginning of the investigation. Although this pleads in favor of the opinion that for the pathogenesis of atherosclerosis hypercholesterolemia is of importance, after all the great majority of the men with hypercholesterolemia at the beginning of the investigation showed no clinical or electrocardiographical signs of atherosclerosis during three years of observation. The importance of primary lesions of the vessel wall for the pathogenesis of atherosclerosis is discussed.


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