TITLE

NONSPECIFIC DELAYED REJECTION OF ALLOGENIC SKIN IN IRRADIATED MICE PROTECTED WITH IMMATURE HEMATOPOIETIC TISSUE

AUTHOR(S)
rogers, Waid; Aust, J. Bradley
PUB. DATE
June 1968
SOURCE
Angiology;Jun1968, Vol. 19 Issue 6, p372
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Strains of adult mice, lethally irradiated, were protected with intravenous suspensions of fetal or newborn liver or adult spleen. Mortality and the "graft-vs.- host" reaction were greatest in the group where allogenic adult spleen was used. A significant decrease in mortality and "graft-us.-host" reaction was observed if allogenic newborn or fetal liver was substituted in the same strain combinations. Use of isogenic tissue or protection of parental animals with F1 hybrid adult or immature tissue resulted in the lowest mortality with no "graft-US.-host" reaction. It was suggested that the advantages of the fetal or newborn liver over adult spleen was due to the immunologic immaturity of the former. Specific tolerance across H2 histocompatibility barriers was achieved in lethally irradiated adult mice protected with allogenic adult spleen and newborn or fetal liver suspensions. Superiority of the F1 hybrid system was observed in achieving tolerance in the parental animal to tissue of the opposite parental type across wide immunologic barriers without the "graft-vs.-host" reaction. The yield of tolerant animals among survivors treated with allogenic fetal or newborn liver was intermediate between those treated with allogenic adult spleen and the special case of parental animals treated with F1 hybrid cell suspensions. Adult mice protected from lethal irradiation with isogenic or allogenic fetal or newborn liver showed a prolonged unresponsive period to allografts foreign to both host and hematopoietic tissue donor. An explanation given for these observations was that the immunologically immature donor cells were able to acquire tolerance to both the host and third strain graft antigens. Premature termination of this universal tolerance period was suggested as due to rejection by either the expanding and maturing foreign population of cells or the recovering host immunologic system in the face of a relatively low antigenic dose from the third strain graft.
ACCESSION #
16369493

 

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