Whittier, John R.; Dhrymiotis, Andreas
October 1965
Angiology;Oct1965, Vol. 16 Issue 10, p575
Academic Journal
1. By the oral route, in acute dosage, the vasorelaxants cyclandelate, isoxsuprine and nylidrin prevented cerebral vasoconstriction, manifested by blocking of the electroencephalogram build-up response to hyperventilation in human volunteers. 2. Nylidrin and isoxsuprine were first and second by order of effectiveness in dosage of twice tablet strength (8 of 10 subjects blocked at 12 mg and 6 of 10 blocked at 20 mg, respectively); cyclandelate was mnch less effective (1 subject blocked at 400 mg). 3. All three drugs were similar in onset time and duration of effect at twice tablet strength (30 or 60 min.). 4. Given intramuscular in dosage of 10 mg, nylidrin and isoxsuprine blocked build-up in all subjects. Onset of effect tended to be earlier for isoxsuprine, and duration of effect longer and less variable. Side effects, especially palpitation, were more frequent with nylidrin in the dosage employed.


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