Plachta, Aaron
August 1962
Angiology;Aug1962, Vol. 13 Issue 8, p380
Academic Journal
Calcified hemangioma of the liver, a rare disease which is confined chiefly to hypertensive women, is described. The roentgen patterns of calcified hemangioma elsewhere in the body are shown to be related. As far as can be ascertained, only one example of calcified cavernous hemangioma of the liver is recorded in the literature to date. Thirteen additional examples in 12 hypertensive women and 1 man, ranging between 67 and 86 of age, are recorded. All the known cases of calcified cavernous hemangioma of the liver have exhibited a tendency to radiate from the center toward the periphery in the form of numerous spicules. It is believed that the roentgen pattern may be used as a clinical diagnostic tool to differentiate between hemangiomas and other calcified lesions of the liver. The gross circumscribed tumor-like mass simulates primary or metastatic carcinoma of the liver, but the biopsy shows it to be calcified hemangioma. Histochemical studies of detailed morphologic features reveal the histogenetic processes of the intima, subintima and stroma; these proliferate a loose, delicate, reticular fibrous connective tissue. That this proliferative activity most likely is initiated by a specialized stimulus is evidenced by the presence of mitosis and mast cells or histiocytes. This activity probably initiates the transition and collagenous formation of intima, subintima, adventitia and stroma and terminate in calcification. The literature of capillary cavernous hemagniomas, as related to age, sex and site with chief reference to the liver, is reviewed in detail, and pertinent references are recorded. There is evidence to propose a triad clinical syndrome consisting of hypertension, hepatomegaly simulating primary or metastatic carcinoma, and a suggestive characteristic roentgen pattern of calcification.


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