Brownlee, George
March 1966
Angiology;Mar1966, Vol. 17 Issue 3, p186
Academic Journal
Examines the use and abuse of vasolidator drugs. Regulatory mechanisms for vascular tone; Factors modifying vascular smooth muscle; Drugs acting directly on smooth muscle.


Related Articles

  • Is prostacyclin an inodilator? Ricksten, Sven-Erik // Intensive Care Medicine;Sep2003, Vol. 29 Issue 9, p1403 

    The article presents information on prostacyclin. Prostacyclin is a naturally occurring substance that in addition to an inhibitory effect of platelet aggregation is a potent vasodilator with a half-life of 2-3 min [1, 2]. Prostacyclin activates the intracellular enzyme adenylyl cyclase, through...

  • Opportunities and challenges in oral therapy. Rajfer, J // International Journal of Impotence Research;2000 Supplement 4, Vol. 12 Issue 5, pS59 

    The major event in normal erectile function is relaxation of the smooth muscle both within the penile arterial system and the cavernosal tissue. The cavernosal smooth muscle is indistinguishable from peripheral vascular smooth muscle from a physiological point of view, ie both are mediated by...

  • Modulation of thiopental-induced vascular relaxation and contraction by perivascular adipose tissue and endothelium. Kassam, S. I.; Lu, C.; Buckley, N.; Gao, Y. J.; Lee, R. M. K. W. // BJA: The British Journal of Anaesthesia;Aug2012, Vol. 109 Issue 2, p177 

    Background Thiopental induces relaxation of vascular smooth muscle cells through its direct and/or indirect vasodilator effects. The perivascular adipose tissue (PVAT) and the endothelium are known to attenuate vascular contraction, and we have recently reported that PVAT potentiates the...

  • Caveolins in vascular smooth muscle: Form organizing function. Hardin, Christopher D.; Vallejo, Johana // Cardiovascular Research;Mar2006, Vol. 69 Issue 4, p808 

    Abstract: Caveolae are becoming increasingly recognized as an important organizational structure for a variety of signal and energy-transducing systems in vascular smooth muscle (VSM). In this review, we discuss the emerging role of the caveolins in organizing and modulating the basic functions...

  • Endothelial Injury Induces Vascular Smooth Muscle Cell Proliferation in Highly Localized Regions of a Direct Contact Co-culture System. Joyce Wong // Cell Biochemistry & Biophysics;Sep2008, Vol. 52 Issue 1, p37 

    Abstract  Though previous studies have indicated a relationship between the proliferation of endothelial cells and vascular smooth muscle cells (VSMCs) in co-culture, the results have been contradictory and the signaling mechanism poorly understood. In this transmembrane co-culture study,...

  • Vasoactivity of Blood Vessels Using a Novel Isovolumic Myograph. Xiao Lu // Annals of Biomedical Engineering;Mar2007, Vol. 35 Issue 3, p356 

    Abstract??The vasoactivity of blood vessel is impaired by cardiovascular disease. The ex-vivo measurements of vasoactivity (wire and pressure myographs) have some inherent difficulties in the characterization of pharmacodynamics and biomechanics. Here, we introduce a novel isovolumic myograph...

  • ISCHEMIC CEREBRAL LESIONS. Van Der Drift, J. H. A. // Angiology;Sep1961, Vol. 12 Issue 9, p401 

    Reviewing the applicability of drug therapy in patients with cerebral vascular insufficiency, the following resume is in order. When low systemic blood pressure is present, vasopressor drugs are indicated, particularly those which increase cardiac output. In patients with systemic hypertension,...

  • Peroxynitrite has potent pulmonary vasodilator activity in the rat. Casey, David B.; Pankey, Edward A.; Badejo, Adeleke M.; Bueno, Franklin R.; Bhartiya, Manish; Murthy, Subramanyam N.; Uppu, Rao M.; Nossaman, Bobby D.; Kadowitz, Philip J. // Canadian Journal of Physiology & Pharmacology;Apr2012, Vol. 90 Issue 4, p485 

    Peroxynitrite (PN) worsens pathological conditions associated with oxidative stress. However, beneficial effects have also been reported. PN has been shown to demonstrate vasodilator as well as vasoconstrictor properties that are dependent upon the experimental conditions and the vascular bed...

  • Regulation of Human Vascular Smooth Muscle Cell Migration by β-Adrenergic Receptors. Johnson, Richard; Webb, Jerry G.; Newman, Walter H.; Zhongbiao Wang // American Surgeon;Jan2006, Vol. 72 Issue 1, p51 

    Migration and proliferation of vascular smooth muscle cells (VSMCs) are two events involved in atherosclerosis, restenosis after balloon angioplasty, and stenosis of grafted vessels. Platelet-derived growth factor (PDGF) found in stenotic vessels is known to induce migration of VSMCs. VSMCs...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics