Rogers, Waid; Edlich, Richard F.; Bradley Aust, J.
July 1969
Angiology;Jul/Aug1969, Vol. 20 Issue 7, p374
Academic Journal
1. There was a definite decrease in flow with tumor size in the mouse mammary carcinoma which was associated with development of central hemorrhagic necrosis with growth. This paralleled the findings previously described in the hamster amelanotic melanoma. In a line of hamster amelanotic melanoma derived from the original tumor, there was no significant change in the mean tumor blood flow with a substantial weight increase. This was associated with little development of central necrosis during growth. 2. In both the mouse and hamster tumors, lissamine green dye stained the peripheral tumor dark and the central tumor light. Mean tissue blood flow estimated with antipyrine-I131 was uniformly higher in the peripheral dark-stained tumor than in the central paler-stained regions. 3. The distribution of radioactive microspheres in both hamster and mouse tumors followed that of lissamine green dye and tissue blood flow as estimated by antipyrine-I131. 4. The uptake of C14-5-FU in the hamster amelanotic melanoma was greater than in the skin and muscle but less than in the stomach and liver. The distribution of this drug within tumor paralleled that of lissamine green, antipyrine-I131 and radioactive microspheres.


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