Gulati, Surinder M.; Kapur, Brij M. L.; Talwar, Janak R.
July 1969
Angiology;Jul/Aug1969, Vol. 20 Issue 7, p367
Academic Journal
Cold injury was produced in 63 rabbits by immersion of the hind limb of each rabbit in a mixture of ice and alcohol at a temperature of -5° to -10° C for 2 hr. Thawing was done slowly at room temperature 27 ± 2° C. Ultimate gross damage was considered as the criteria for the assessment of efficacy of oxyphenbutazone in the dosage of 20 and 60 mg per kg orally in three equal divided doses. Oxyphonbutazone helped in the prevention or reduction of tissue damage. Possible mechanism of action is discussed.


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