TITLE

A LONG-TERM STUDY OF COMBINED GUANETHIDINE AND HYDROCHLOROTHIAZIDE THERAPY IN THE MANAGEMENT OF HYPERTENSION

AUTHOR(S)
Kert, Morley J.; Dashe, Alfred M.; Mailman, Richard H.; Roth, Samuel I.; Zager, Albert
PUB. DATE
November 1962
SOURCE
Angiology;Nov1962, Vol. 13 Issue 11, p511
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. Fifty-five outpatients were treated with guanethidine alone or in combination with hydrochlorothiazide in a long-term controlled study. 2. A clinically significant antihypertensive effect was demonstrated. This response was potentiated by hydrochlorothiazide. 3. The side effects were common but rarely serious enough to discontinue the drug; often the side effects diminished when therapy was continued. 4. Tolerance to the drug was seen in a few patients but usually responded to increase of dosage. 5. In this study, guanethidine proved to be a potent, effective antihypertensive medication for use with fully ambulatory outpatients. By concomittant administration of hydrochlorothiazide a substantial reduction could be made in the guanethidine dosage while the antihypertensive response was augmented.
ACCESSION #
16369292

 

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