TITLE

INFLUENCE OF RESERPINE AND GUANETHIDINE ON VASCULAR REACTIVITY AND ANTIHISTAMINE CONSTRICTOR ACTION IN THE MICROCIRCULATION

AUTHOR(S)
Altura, Burton M.; Zweifach, Benjamin W.
PUB. DATE
July 1966
SOURCE
Angiology;Jul1966, Vol. 17 Issue 7, p493
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Experiments were designed to evaluate the peripheral vascular effects on the rat mesocecum of two antihypertensive agents, reserpine and guanethidine, in regard to vascular reactivity and antihistamine constrictor action. The administration of guanethidine, within 5 min., produced an increase in vascular reactivity to topically applied epinephrine and norepinephrine. This agent also produced an increased venular constriction to topically applied serotonin as well as to antihistamines. A similar sensitization to topical catecholamines and serotonin was recorded 20 min. after the administration of reserpine. However, antihistamine constrictor activity remained essentially that observed in control animals. The chronic administration of guanethidine yielded results somewhat different from that of reserpine, although both types of treatment produced widespread microvascular dilation. Repeated daily systemic injections of reserpine were found to produce an increase in vascular reactivity to topical epinephrine, norepinephrine and antihistamines as well as to topical vasopressin, whereas chronic administration of guanethidine was found to depress catecholamine constrictor action without any effect on topically applied serotonin, vasopressin, histamine or antihistaminic agents. These catecholamine depletors clearly failed to prevent the previously observed antihistamine constrictor action on the microcirculation. The findings are discussed in relation to histamine levels in the terminal vascular bed.
ACCESSION #
16369226

 

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