Strandness Jr., D. E.; Parrish, D.; Dickson, A. H.; Bell, J. W.
November 1964
Angiology;Nov1964, Vol. 15 Issue 11, p479
Academic Journal
The peripheral hemodynamic changes in waking animals and in those anesthetized with pentobarbital and morphine-thiopental have been described. From this study the following conclusions were drawn: 1. The waking, well-trained dog shows marked fluctuations in sympathetic activity and skin blood How with minimal stimulation. It was impossible to attain a stale of vasomotor stability in the waking animal. 2. Intravenous pentobarbital sodium results in an immediate pronounced vasodilation, followed by a decrease in both femoral artery and skill blood flow. Cardiac output declined to a significant degree during the period of observation. 3. Morphine-thiopental resulted in a lighter anesthetic level but in a more unpredictable pattern of change in skin and muscle blood flow and cardiac output. 4. The possible implications of these observations in peripheral vascular research are discussed.


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