Kask, Endel
January 1962
Angiology;Jan1962, Vol. 13 Issue 1, p35
Academic Journal
Known defects in enzyme activities in arteriosclerosis are reviewed, with emphasis on the arterial wall as a metabolically active organ. The author is of the opinion that such defects are real, as verified by the multiple investigative reports, and that it is likely that at least some of them are primary' and of greater importance in the etiology of arteriosclerosis than variations in the quantity or quality of substrate offered to the enzymes in the form of food. The major part of arteriosclerosis research appears to have taken the opposite stand so far, but this stand seems to simply ignore the inevitable dependence of all substrates on enzyme activities for their metabolism, and that the interconversion of the different classes of food into each other in the organism makes the withholding of one class from the diet unlikely of definitive success in dealing with the perennial and extensive problem of arteriosclerosis. The author also describes his own observations in four arteriosclerotic persons who received a relatively long-term treatment by a combination of metabolic (oxidative) enzymes.


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