Cohen, Irvin M.
January 1962
Angiology;Jan1962, Vol. 13 Issue 1, p1
Academic Journal
Tranquilizers are unique sedatives having high therapeutic indices. They are distinguishable from older sedatives chiefly by their lack of cerebral depressant action and greater latitude of dosage application. There is some evidence that they have curative properties but their primary action appears to be a nonspecific inhibition of anxiety, agitation and/or aggression. The value of tranquilizers in the treatment of patients with cardiac and vascular disease depends on the individual case. If chemical sedation is required, tranquilizers permit quantitatively greater sedation without hypnotic effects than is possible with previously known, sedatives. Successful tranquilizer therapy in cardiac and vascular disease, as in all other disease categories, depends on proper selection of patients, scaling of dosage to the needs of the patient and setting of reasonable therapeutic goals.


Related Articles

  • Synthesis and Antinociceptive Behaviors of New Methyl and Hydroxyl Derivatives of Phencyclidine. Ahmadi, A.; Kermani, M.; Naderi, N.; Hajikhani, R.; Rezaee, N. M.; Javadi, M.; Niknafs, B. N. // Current Medicinal Chemistry;Feb2012, Vol. 19 Issue 5, p763 

    Phencyclidine (I) and its derivatives show such pharmacological behaviors as analgesic, anticonsulvant, anti-anxiety and anti-depressant, while interacting with central nervous system. In this study, new methyl and hydroxyl derivatives of PCP were synthesized and their antinociceptive behaviors...

  • downers.  // Downers Fast Facts;6/1/2007, p1 

    The article provides information on downers, a name for depressant drugs, known medically as sedative-hypnotics. The group includes a range of chemicals that depress or slow down central nervous system functions. Two drug families have long dominated the depressant group: barbiturates and...

  • Psychoactive Drugs. Smith, David E.; Fort, Joel; Craton, Delores L. // Journal of Psychoactive Drugs;Apr2007, Vol. 1 Issue 1, p127 

    The article offers information on psychoactive drugs which can be a reference for the Haight-Ashbury Medical Clinic staff in San Francisco, California. It categorizes the drugs into sedative-hypnotics, narcotics, and central nervous system (CNS) stimulants. Information on the generic name and...

  • Anxiolytics and Sedatives and Risk of Fractures: Effects of Half-life. Vestergaard, Peter; Rejnmark, Lars; Mosekilde, Leif // Calcified Tissue International;Jan2008, Vol. 82 Issue 1, p34 

    To study the risk of fractures associated with anxiolytics, sedatives, and hypnotics, we conducted a case-control study. Cases were all subjects with any fracture during the year 2000 ( n = 124,655). For each case, three controls ( n = 373,962) matched on age and gender were randomly drawn from...

  • zopiclone.  // Royal Society of Medicine: Medicines;2002, p580 

    This article presents information on zopiclone which, a newly introduced hypnotic drug which works in the same way as a benzodiazepine. It can be used for the short-term treatment of insomnia. Administration is oral.

  • Calming, but Dangerous.  // USA Today Magazine;Feb91, Vol. 119 Issue 2549, p14 

    Focuses on the dangers of benign tranquilizers. Possible central nervous system depression.

  • Pharmacology and Therapeutics of Gabapentin in the Treatment of Psychiatric Disorders; Present and Future Perspectives. Megna, J. L.; Iqbal, M. M.; Aneja, A. // Current Neuropharmacology;Sep2003, Vol. 1 Issue 3, p187 

    Gabapentin is an antiepileptic drug, which decreases neuronal excitability and may act by increasing the availability of gamma-aminobutyric acid or by inhibiting Ca2+ channels. It has safe pharmacokinetic and side effect profiles. Not surprisingly, it has been tested as a treatment in a number...

  • FOREWORD. Salt, Tom // Current Neuropharmacology;Sep2003, Vol. 1 Issue 3, p1 

    This, third, issue of Current Neuropharmacology marks a new departure from the format of previous issues. As part of this issue there is a special section of review papers centred around the theme of Gabapentin, a drug originally developed as an anti-epileptic but which has found uses in other...

  • Genetic and phenotypic analysis of seizure susceptibility in PL/J mice. Kitami, Toshimori; Ernest, Sheila; Gallaugher, Laura; Friedman, Lee; Frankel, Wayne N.; Nadeau, Joseph H. // Mammalian Genome;Sep2004, Vol. 15 Issue 9, p698 

    Epilepsy is one of the most common but genetically complex neurological disorders in humans. Identifying animal models that recapitulate human epilepsies is important for pharmacological studies of anticonvulsants, dissection of molecular and biochemical pathogenesis of epilepsy, and discovery...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics