Cholesterol Crystal Embolization: A Review of 221 Cases in the English Literature

Fine, Michael J.; Kapoor, Wishwa; Falanga, Vincent
October 1987
Angiology;Oct1987, Vol. 38 Issue 10, p769
Academic Journal
Cholesterol crystal embolization (CCE) frequently presents with nonspecific manifestations that mimic other systemic diseases. The authors reviewed 221 cases of histologically proven CCE in the English literature to define the clinical, laboratory, and pathologic characteristics of this disorder. CCE affected predominantly elderly males (mean age sixty-six) with a frequent history of hypertension (61%), atherosclerotic cardiovascular disease (44%), renal failure (34%), and aortic aneurysms (25%) at presentation. At least one possible predisposing factor was present in 31% and included operative and radiological vascular procedures and the use of anticoagulants. Cutaneous findings (34%) and renal failure (50%) were two of the most common clinical findings throughout the course of CCE. The nonspecific signs and symptoms included: fever (7%), weight loss (7%), myalgias (4%), and headache (3%). Premortem diagnoses were established in 31% of patients most commonly by biopsy of the muscle, skin, and kidney. Mortality was high (81%) and was most commonly due to multifactorial, cardiac, and renal etiologies. The authors conclude that CCE should be strongly considered in elderly patients with atherosclerotic vascular disease who have the onset of renal insufficiency and cutaneous manifestations. CCE may be confirmed by a skin or muscle biopsy.


Related Articles

  • Atorvastatin mediates increases in intralesional BAX and BAK expression in human end-stage abdominal aortic aneurysms. Schweitzer, Morris; Mitmaker, Benjamin; Obrand, Daniel; Sheiner, Nathan; Abraham, Cherrie; Dostanic, Stevan; Chalifour, Lorraine E. // Canadian Journal of Physiology & Pharmacology;Nov2009, Vol. 87 Issue 11, p915 

    Chronic apoptosis activation may participate in abdominal aortic aneurysm (AAA) expansion. Statin treatment slows AAA progression independent of cholesterol lowering. We hypothesized that Atorvastatin treatment alters apoptosis protein expression and activation in AAAs. Protein was isolated from...

  • Treatment of End-Stage "Trash Feet" With the End-Diastolic Pneumatic Boot. Filip, John R.; Dillon, Richard S. // Angiology;Apr/May2008, Vol. 59 Issue 2, p214 

    This study reassessed the clinical effect of Circulator Boot (GB) therapy in patients with cholesterol embolization syndrome (CES) of the lower extremities. The medical records were reviewed of 27 patients consecutively referred to the Bryn Mawr Wound Care and Vascular Center with CES who had...

  • Low-cholesterol diet also works for postmenopausal women.  // Modern Medicine;Oct94, Vol. 62 Issue 10, p21 

    Reports on a study conducted by Margo A. Denke which found that a low-cholesterol diet may benefit postmenopausal women with hypercholesterolemia. Low-density lipoprotein levels of women subjects; Cholesterol and fat content of low-cholesterol diet given to subjects.

  • Blood fats vary widely on strict diets.  // Executive Health's Good Health Report;Oct97, Vol. 34 Issue 1, p4 

    Reports on study findings indicating changes in cholesterol levels of individuals on a prescribed diet called the National Cholesterol Education Program Step 2 Diet. Role of genetic differences; Process of the study on 120 healthy men and women; Large variability in response to diet.

  • Just whites.  // U.S. News & World Report;10/24/94, Vol. 117 Issue 16, p89 

    Comments that substituting two egg whites for a whole egg helps cooks reduce cholesterol and fat. Information on powdered egg whites that are available that go unnoticed in baking recipes; Contact point.

  • Macho, macho meals. Wolfe, Jack // Men's Health;Jul/Aug96, Vol. 11 Issue 6, p110 

    Presents suggestions for cutting cholesterol from food. Use of lean ground beef or turkey for hamburgers; Preparing flapjacks; Suggestions for a leaner chili con carne; Cholesterol-lowering properties of calcium in sardines.

  • Q High cholesterol runs in my family. Can diet really make a difference? Stork, Travis // Redbook;Feb2012, Vol. 218 Issue 2, p75 

    The article presents an answer to the question of whether diet can help if high cholesterol runs in the family.

  • DASH diet lowers cholesterol levels. Lo Buono, Charlotte; Roantree, Rosie; Saunders, Carol S. // Patient Care;9/15/2001, Vol. 35 Issue 17, p8 

    Focuses on the benefits of the Dietary Approaches to Stop Hypertension (DASH) diet. Average cholesterol levels reduced following the DASH diet.

  • Quick-start breakfasts for all-day energy.  // Men's Health;Apr91, Vol. 6 Issue 2, p39 

    Lists several low-cholesterol breakfast meal. Includes baked apples in the microwave; Pudding of leftover rice; Sliced peaches and cottage cheese on a toasted English muffin.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics