Selye, H.; Bajusz, E.; Grasso, S.; Mendell, P.
October 1960
Angiology;Oct1960 Part 1, Vol. 11 Issue 5, p398
Academic Journal
Surgical techniques are described that regularly permit the occlusion of coronary arteries or veins at precisely defined points in the rat. The simplicity and speed of these procedures make it possible for technicians, even without previous surgical experience, to perform such operations routinely in large series, for the screening of factors that might influence the course of coronary infarction. The advantages of these methods are ascribed principally to four factors: (1) establishment (on the basis of vascular injection preparations) of readily visible landmarks that help to locate vessels that cannot be seen (clearly; (2) use of a binocular loupe and a strong frontal lamp; (3) exposure of the cardiac vessels with a minimum of accidental trauma, owing to the use of a costotomy and a special ‘thimble, retractor’; (4) elimination of the need for pressure respiration. The infarcts thus produced in healthy young cardiac muscle by the selective, sudden occlusion of certain coronary vessels differ in many respects from those elicited in experimental animals by chemical means; these differences, as well as the application of the new techniques to further research, are briefly discussed.


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