TITLE

A DOUBLE BLIND EVALUATION OF THE ANTIHYPERTENSIVE EFFECT OF RESERPINE, PHENOBARBITAL, HYDRALAZINE, SYROSINGOPINE, AND PLACEBO IN AMBULATORY SUBJECTS

AUTHOR(S)
Sosa, Gustavo; Morita, Yoshikazu; Mader, Ivan J.
PUB. DATE
October 1960
SOURCE
Angiology;Oct1960 Part 1, Vol. 11 Issue 5, p381
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The antihypertensive effect of the oral administration of reserpine, syrosingopine, hydralazine, and phenobarbital in ambulatory patients was evaluated, using the double blind technique, Phenobarbital seemed to have no significant effect on either systolic or diastolic pressure compared to placebo, Reserpine had no significant effect on systolic pressure, but lowered the diastolic pressure slightly compared to either placebo or phenobarbital, Syrosingopine, in the dosage used, was less effective than reserpine. The addition of hydralazine to a regimen of reserpine did not further decrease the blood pressure and did not significantly increase the renal plasma flow. Side effects were arbitrarily graded and statistically analyzed. The clinical significance of the results is discussed.
ACCESSION #
16365661

 

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