Halprin, Harry
August 1960
Angiology;Aug1960, Vol. 11 Issue 4, p348
Academic Journal
1. A new amine oxidase regulator, Marplan, in daily doses of from 15 to 40 mg, was given to 15 patients with angina pectoris and 2 with symptoms associated with neurocirculatory disorders over periods of from 1 to 6 months. 2. Significant relief of pain was reported by 14 of the 17 patients together with an increased capacity for physical activity. 3. Of 12 patients previously dependent upon nitroglycerin, 10 were able to discontinue it completely and 2 to reduce their intake from 12 to 20 and over 20 tablets to an average of 2 daily. 4. Electrocardiographic and other evidence appear to indicate that although the drug relieves pain, it does not improve the underlying disease process. One exception was noted, and this of sufficient significance to suggest the advisability of further study. 5. The drug had no deleterious effect on adjuvant therapy such as anticoagulant administration. 6. Except for 1 case of pruritis, side effects were not considered serious enough to terminate medication. They were reported in 7 patients. 7. The results are definitely favorable to the use of Marplan in the dosages given fur the relief of angina pectoris.


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