TITLE

INDICATIONS, CONTRAINDICATIONS AND TREATMENT WITH MONOAMINE OXIDASE INHIBITING ANTIDEPRESSANT DRUGS

AUTHOR(S)
Sainz, Anthony
PUB. DATE
February 1960
SOURCE
Angiology;Feb1960 Part 2, Vol. 11 Issue 1, p94
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The monoamine oxidase inhibitors, based on modifications of hydrazine, have been defined, and their pharmacologic position, e.g., as antidepressants rather than stimulants, analeptics, etc., has been specifically clarified and documented. An operational classification and definition of the depressions has been made, based on their therapeutic response to drugs. Using Nardil as an example of this class of drugs, a comprehensive description of the methodology of administration, determination of the maintenance dosages and criteria for discontinuation has been made. Side effects with this medicament and their control have been fully described and discussed. The recognition and treatment of accidental or intentional overdoses has been made. Specific contraindications have been defined and discussed. The action of Nardil, finally, has been briefly outlined in other conditions such as rheumatoid arthritis, angina pectoris and psoriasis. Considerations on the mechanism of action and dosage levels were discussed. It is concluded that this group of drugs, in addition to their unquestionable therapeutic value in the endogenous depressions, may also be of value in other fields, and are shedding an important new light in many old medical problems.
ACCESSION #
16365500

 

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