Takayasu's Disease in Middle-Aged Women. A Clinicopathologic Study

di Giacomo, V.; Meloni, F.; Transi, M. G.; Nigro, D.; Sciacca, V.
February 1985
Angiology;Feb1985, Vol. 36 Issue 2, p70
Academic Journal
Often patients with Takayasu's disease (TD), all women, hospitalized in our Service in the last 5 years, seven were more than 38 years old. In these subjects the mean age at diagnosis was 41.2 years. These findings confirm that, in Italy as in other Western countries, including the United States, the diagnosis of TD is usually made later than in Asia and Latin America. This circumstance is probably related to actual later onset of the disease. In most of our cases both the anamnestic data and the angiographic findings demonstrated an evolution of the disease with further involvement of other arteries. Several arterial biopsies consistently showed, within a diffuse sclerosis, more or less extensive inflammatory aggregates characterized by a lymphoplasmacellular infiltration often associated with giant cells. Such a pattern testifies to the persistence of an active arteritis even a long time after the onset of the disease - "persistent active arteritis" instead of "residual arteritis." Pointing out such an evolution of the TD in every stage, our clinicopathologic study emphasizes the importance of a careful followup of the patients; it also advises continuous treatment with corticosteroid drugs, sometimes associated with immunosuppressors, to attain a reduction of the inflammatory process.


Related Articles

  • Terapijski pristup u progresivnom toku Takayasuovog arteritisa. Petrovic-Rackov, Ljiljana // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Jun2006, Vol. 63 Issue 6, p615 

    Background. Takayasu's arteritis (TA) is a nonspecific autoimmune inflammation manifested with systemic large vessel vasculitis which affects predominantly the aorta and its main branches. Case report. We presented a 40-year-old woman with a two-year history of the symptoms of compromised...

  • Evaluation of a new algorithm in classification of systemic vasculitis. L.-J. Liu; M. Chen; F. Yu; M.-H. Zhao; H.-Y. Wang // Rheumatology;May2008, Vol. 47 Issue 5, p708 

    Objective. Recently, a new consensus algorithm for classification of ANCA-associated vasculitis (AAV) and PAN had been proposed by Watt et al. for epidemiological studies. In order to evaluate this algorithm, the current study used the algorithm to reclassify the patients with AAV and PAN in our...

  • Takayasu’s arteritis presenting with bilateral pulmonary granulomatosis. Cheng-De Yang; Jia-Lin Teng; Yue-Ying Gu; Shun-le Chen // Clinical Rheumatology;Apr2007, Vol. 26 Issue 4, p612 

    Takayasu’s arteritis (TA) is a vasculitis characterized by inflammation and obliteration of intermediate to large-size arteries. We report a case of Takayasu’s arteritis with a presentation of bilateral pulmonary nodular infiltrates in a 21-year-old man. An open-lung biopsy showed...

  • Color-coded sonography in suspected temporal arteritis-experiences after 83 cases. Reinhard, Matthias; Schmidt, Dieter; Hetzel, Andreas // Rheumatology International;Nov2004, Vol. 24 Issue 6, p340 

    Color-coded sonography is an interesting option for the diagnosis of temporal arteritis. We present our experiences regarding examination technique and diagnostic accuracy, comparing biopsy and clinical results in a series of 83 patients with suspected temporal arteritis. A dark halo around the...

  • Medium- and Large-Vessel Vasculitis. Weyand, Cornelia M.; Goronzy, Jörg J. // New England Journal of Medicine;7/10/2003, Vol. 349 Issue 2, p160 

    Discusses mechanisms of disease in medium and large vessel vasculitis. The pathogenic model of giant-cell arteritis; T-cell-dependent vasculitic inflammation in giant-cell arteritis; Vessel-wall inflammation; Granuloma formation in giant-cell arteritis; Mechanisms of tissue damage in giant-cell...

  • F-18 Fdg PET/CT Findings of a Patient with Takayasu Arteritis Before and After Therapy. Sağer, Sait; Yılmaz, Sabire; Özhan, Meftune; Halaç, Metin; Ergül, Nurhan; Çiftci, Hediye; Çermik, T. Fikret // Molecular Imaging & Radionuclide Therapy;Apr2012, Vol. 21 Issue 1, p32 

    Vasculitis is defined as inflammation and necrosis with leukocytic infiltration of the blood vessel wall. Takayasu arteritis is a chronic inflammatory arteritis that primarily involves the aorta and its main branches. A 64-year-old female patient with a 2-month history of fever of unknown origin...

  • Hepatit C Virüse Bağı Kriyoglobulinemik Vaskülitli Bir Olgu. Karataş, Ömer; Diraçoğlu, Demirhan; Ekmekçi, Ahmet; Mete, Özgür; Aksoy, Cihan // Turkish Journal of Physical Medicine & Rehabilitation / Turkiye ;dic2008, Vol. 54 Issue 4, p177 

    HCV is a universally common and serious health problem. Vasculitis is a group of illnesses characterized by inflammatory alteration of the blood vessel wall and development of necrosis and granuloma in some circumstances. In this article, vasculitis of cryoglobulinemia which appeared in a...

  • Retinal vasculitis: a review. Sanders, M. D. // Journal of the Royal Society of Medicine;Dec1979, Vol. 72 Issue 12, p908 

    The article illustrates patterns of involvement of the arteries in lupus erythematosus and capillary involvement in certain other conditions related to vasculitis. It has been well described the occurrence of systemic vasculitis following viral infections. Furthermore, a systemic disease process...

  • Frosted branch angiitis, neuroretinitis as initial ocular manifestation in Behçet disease. Al-Mujaini, Abdullah; Wali, Upender K. // Indian Journal of Ophthalmology;May2011, Vol. 59 Issue 3, p240 

    Behçet disease is an idiopathic, multisystem disorder characterized by recurrent episodes of orogenital ulceration and vasculitis of the veins and arteries of all calibers. Ocular involvement may affect the conjunctiva, sclera, uveal tract, vitreous, blood vessels, and retina. Many theories...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics