TITLE

THE EFFECTS OF PHENYL-2-BUTYL NORSUPRIFEN HYDROCHLORIDE ON THE SYSTEMIC AND CORONARY HEMODYNAMICS AND METABOLISM OF THE INTACT DOG

AUTHOR(S)
Maxwell, George M.; White, Douglas H.; Crumpton, Charles W.; Castillo, Cesar A.
PUB. DATE
April 1960
SOURCE
Angiology;Apr1960, Vol. 11 Issue 2, p133
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effects of an acute intravenous injection of phenyl-2-butyl norsuprifen hydrochloride upon the intact anesthetized dog are presented. In this study, the drug increased heart rate and decreased systemic pressure and resistance. Cardiac output was increased with a decrease in pulmonary arterial resistance. The coronary blood flow and cardiac metabolic rates for O2 and CO2 increased, and these changes were inimical to heart efficiency. These myocardial changes are flue in the main to the tachycardia caused by the drug.
ACCESSION #
16365415

 

Related Articles

  • The Use of Beat-to-Beat Electrocardiogram Analysis to Distinguish QT/QTc Interval Changes Caused by Moxifloxacin From Those Caused by Vardenafil. Fossa, A. A.; Langdon, G.; Couderc, J.-P.; Zhou, M.; Darpo, B.; Wilson, F.; Wallis, R.; Davis, J. D. // Clinical Pharmacology & Therapeutics;Sep2011, Vol. 90 Issue 3, p449 

    QT correction factors (QTc) can cause errors in the interpretation of drug effects on cardiac repolarization because they do not adequately differentiate changes when heart rate or autonomic state deviates from the baseline QT/RR interval relationship. The purpose of our study was to determine...

  • Assessment of the pro-arrhythmic potential of anti-arrhythmic drugs: an experimental approach. Verduyn, S. Cora; van Opstal, Jurren M.; Leunissen, Jet D.; Vos, Marc A.; Verduyn, S C; van Opstal, J M; Leunissen, J D; Vos, M A // Journal of Cardiovascular Pharmacology & Therapeutics;Jan2001, Vol. 6 Issue 1, p89 

    The article presents information on the assessment of the pro-arrhythmic potential of anti-arrhythmic drugs. Pro-arrhythmic activity is a feared side effect of almost all antiarrhythmic drugs. One of these proarrhythmic events is the occurrence of Torsude de Poitiles (TdP) arrhythmias, a...

  • Pharmacodynamic study on acute hypotensive activities of Carissa carandas extract in normal rats. Shamim, Sumbul; Ahmad, Syed Iqbal // Pakistan Journal of Pharmaceutical Sciences;Jul2012, Vol. 25 Issue 3, p577 

    This study aims to evaluate the effect of Carissa carandas extract on cardiovascular function of normal rats. Intravenous bolus injection of this extract in the doses of 5 mg kg-1 -45 mg kg-1, produced dose dependent reduction in arterial blood pressure (p<0.001). The 45mg/kg dose caused a...

  • Spectral analysis of heart rate variability and pulmonary responses to topical applications of a 2% aminophylline-based thigh cream. Marks, B L; Katz, L M; Haky, J E; Foss, W M; Torok, D J // International Journal of Obesity & Related Metabolic Disorders;Feb1999, Vol. 23 Issue 2, p198 

    OBJECTIVE: Noninvasive assessment of the immediate and delayed cardiopulmonary response to a 2% amino-phylline-based topical thigh reducing cream. DESIGN: Prospective, double-blind, randomized, counterbalanced study with application of: no cream (NC), placebo cream (PC) or 2% aminophylline cream...

  • Valsartan/Hydrochlorothiazide. Langtry, H.D.; McClellan, K.J. // Drugs;May1999, Vol. 57 Issue 5, p751 

    â–´ Valsartan/hydrochlorothiazide (HCTZ) combines an angiotensin II AT receptor blocker with a thiazide diuretic to produce additive blood pressure reductions without major effects on heart rate. â–´ HCTZ did not significantly alter valsartan pharmacokinetics; during combination therapy,...

  • Errors associated with the concentration of epinephrine in endonasal surgery. Matoušek, Petr; Komínek, Pavel; Garčic, Antonín // European Archives of Oto-Rhino-Laryngology;Jul2011, Vol. 268 Issue 7, p1009 

    This paper presents two cases of using erroneous concentrations of epinephrine during endonasal surgery. The two patients discussed were part of a larger study aimed at monitoring the absorption of epinephrine upon injection into the nasal mucosa. During this study, we observed major...

  • Supraventricular and ventricular tachycardia. Hammond, Cecile // RN;Mar84, Vol. 47 Issue 3, p94 

    Discusses the distinction between supraventricular tachycardia and ventricular tachycardia. Information on atrial and ventricular activity; Key to treating supraventricular or ventricular tachycardia; Conversion of fast heart rates that originate above the ventricles to normal sinus rhythm.

  • Age-corrected intraoperative tachycardia correlates with postoperative electrocardiographic alterations. Kurokochi, Nobuo // Journal of Anesthesia;2001, Vol. 15 Issue 1, p11 

    Purpose. The intrinsic heart rate (IHR) has been calculated by an age-dependent formula; 118.1 - 0.57 x Age (years). The aim of this study was to examine whether intraoperative tachycardia of different criteria correlates with the incidence of alterations of postoperative electrocardiograms...

  • Supernormal conduction mimicking a supraventricular capture beat during wide complex tachycardia. Niroomand, F. // Heart;Sep2002, Vol. 88 Issue 3, p295 

    Presents a case of a 64-year-old woman diagnosed with a supraventricular capture beat and ventricular tachycardia. Case history; Explanation for the pseudocapture beat; Observance of supernormal excitability and conduction during a short period at the end of the recovery phase of the action.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics