Thrombocytopenia and Lupus-Like Anticoagulant in a Patient with Peripheral Vascular Disease: Response to Infusion of Prostacyclin

Fonseca, V.; Mikhailidis, D. P.; Boag, F.; Barradas, M. A.; Jeremy, J. Y.; Gracey, L.; Dandona, P.
April 1985
Angiology;Apr1985, Vol. 36 Issue 4, p258
Academic Journal
A 46 year old man with intermittent claudication due to severe peripheral vascular disease had a circulating lupus like anticoagulant (LLAC), thrombocytopenia (79 � 10&frac91;) markedly reduced platelet survival and ii normal bone marrow. He was treated with intravenous prostacydlin (PGI2) infusions which resulted in improvement of the patient's exercise tolerance and normalisation of his platelet count (300 � 10&frac91;) and platelet aggregation could then be assessed. The platelets were markedly hyperaggregable and generated supranormal quantities of thromboxane A2 A diagnosis of consumptive thrombocytopenia secondary to peripheral vascular disease and platelet hyper aggregability was made. Despite therapy with aspirin and dipyridamole, gradual Sd progressive reduction in platelet count followed and his exercise tolerance declined over the next three months. Immunoglobulin prepared from the patient's serum did not inhibit vascular PGI2 synthesis in vitro. To our knowledge this is the first reported case of consumptive thrombocytopenia due to severe peripheral vascular disease and platelet hyperaggregability. PGI2 administration caused a transient resolution of these features which was not sustained by aspirin and dipyridamole.


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