Alpha and Beta-Blockade and Beta-Stimulation in Raynaud's Syndrome: A Double-Blind, Placebo Controlled, Single Dose Study

Cleophas, Ton J. M.; Fennis, Jan F. M.; van 't Laar, Albert
April 1985
Angiology;Apr1985, Vol. 36 Issue 4, p219
Academic Journal
We examined in a double blind fashion and placebo controlled the effects of some alpha and beta adrenergic receptor agonists and antagonists on the recovery of finger skin temperature 12 mm after finger cooling (5 mm waterbath for both hands) in twelve patients with Raynaud's syndrome. A favourable effect was established on phenoxybenzamine 20 mg as compared to placebo. A significant but rather small effect on orciprenaline 10 mg. The beta-agonists prenalterol (10 mg) and terbutaline (S mg) did not influence the recovery of finger skin temperature. The beneficial effect of phenoxybenzamine 20 mg was not influenced by the addition of beta-agonists (prenalterol 10 mg or terbutaline S mg) or a beta-blocker (propranolol 40 mg). The beta-agonists terbutaline and orciprenaline caused a fall in diastolic pressure and an increase in heart rate. These effects presumably were connected with one collaps and three near-collapses. On alpha- and beta-blocker (phenoxybenzarnine and propranolol) a decrease in systolic pressure appeared, whereas diastolic pressure did not significantly differ from the placebo value. While physical exercise is considered to exacerbate the hypotensive effect of alpha-blockers, a fall in blood pressure during physical exercise could not be established in our experiments after the addition of propranolol to the alpha- blocker phenoxybenzamine. Our results suggest that an alpha-blocker is a good choice in Raynaud's syndrome, whereas the addition of a beta-blocker may have some advantages.


Related Articles

  • Long-Acting β2-Agonists in Asthma: Not so SMART? Currie, Graeme P.; Lee, Daniel K. C.; Lipworth, Brian J. // Drug Safety;2006, Vol. 29 Issue 8, p647 

    Asthma is a worldwide chronic disorder that is characterised by airway inflammation and hyper-responsiveness, which results in intermittent airflow obstruction and subsequent perception of symptoms and exacerbations. Inhaled corticosteroids are a fundamental component in the prevention of the...

  • Treatment of Raynaud's Syndrome with Adrenergic Alpha-Blockade with or without Beta-Blockade. Cleophas, Ton J. M.; van Lier, Henk J. J.; Fennis, Jan F. M.; van 't Laar, Albert // Angiology;Jan1984, Vol. 35 Issue 1, p29 

    In a double blind placebo-controlled cross-over trial of 24 weeks 31 patients with Raynaud's syndrome were treated with the alpha-blocker phenoxybenzamine (10–20 mg daily) and with the combination of the alpha-blocker phenoxybenzamine (10–20 mg daily) and the beta-blocker sotalol...

  • Steroid or Steroid Plus Long-Acting Beta Agonist for Mild Persistent Asthma.  // Neurology Alert;May2011 Supplement, p1 

    The article discusses results of a study which showed that inhaled corticosteroids (ICS)/long-acting beta agonist (LABA) is superior to placebo than ciclesonide (CIC) in asthma control, referencing the report "Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate...

  • Inhibitory effects of landiolol and nicardipine on thiopental-induced yawning in humans. Oshima, Tsutomu; Murakami, Tatsuo; Saitoh, Yuhji; Yokota, Miyuki; Kasuya, Yoshiko // Journal of Anesthesia;2010, Vol. 24 Issue 2, p168 

    Either the calcium (Ca2+)-channel blocker nicardipine or the β1-adrenoceptor antagonist landiolol may be intravenously (IV) administered to reduce the hemodynamic responses to tracheal intubation. In this study, we examined the effects of these drugs on the yawning response elicited by...

  • Gastroprotective effects of β3-adrenoceptor agonists on water immersion plus restraint stress-induced gastric ulcer in rats. Paul, A.; Goswami, S.; Santani, D. // Indian Journal of Pharmacology;Jun2004, Vol. 36 Issue 3, p151 

    Objective: To evaluate the gastroprotective effects of β3-adrenoceptor agonists CGP 12177A and SR 58611A, on water immersion plus restraint stress (WIRS)-induced gastric ulceration in rats. Material and Methods: Drugs were administered (5, 10 and 15 mg/kg, p.o.) 30 min prior to the...

  • Fluticasone Propionate Aerosol: Efficacy in Patients with Mild to Moderate Asthma. Sheffer, Albert L.; LaForce, Craig; Chervinsky, Paul; Pearlman, David; Schaberg, Amy // Journal of Family Practice;Apr1996, Vol. 42 Issue 4, p369 

    Background. This double-blind, randomized, parallel-group, placebo-controlled study investigated the efficacy and tolerability of fluticasone propionate aerosol (25, 50, or 100 µg bid for 12 weeks) administered as primary maintenance therapy to patients whose mild to moderate asthma was...

  • β-adrenoceptor agonists increase cardiovascular risk.  // Reactions Weekly;8/21/2004, Issue 1015, p5 

    Discusses research being done on cardiovascular effects of beta-agonists on patients with asthma. Reference to a study by S. R. Salpeter et al., published in the June 2004 issue of the journal "Chest"; Background on an increase in the risk of the disease; Comparison to the effectiveness of placebo.

  • Gly/Gly and Arg/Arg genotype responses to albuterol differed in mild asthma.  // ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p43 

    The article cites a study which discusses the use of regularly scheduled albuterol treatment in asthma. The study was published in the 2004 issue of the journal "Lancet." In mild asthma, patients with the Gly/Gly genotype had better asthma control with albuterol than when it was withdrawn, and...

  • Review: commonly used pharmacological treatments for bronchiolitis in children do not seem to be effective. King, V. J.; Viswanathan, M.; Bordley, W. C. // Archives of Disease in Childhood;Dec2004 Supplement, Vol. 89, pep79 

    The article focuses on the effectiveness of commonly used pharmacological treatments in children with bronchiolitis. 44 RCTs of commonly used interventions met the selection criteria. Study quality was rated as excellent in 7 RCTs, good in 20 RCTs, fair in 15 RCTs, and poor in 2 RCTs, Nebulised...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics