TITLE

Clinical Pharmacokinetics and Metabolism of Bevantolol

AUTHOR(S)
Latts, Jeffrey R.
PUB. DATE
March 1986
SOURCE
Angiology;Mar1986 Part 2, Vol. 37 Issue 3, p221
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bevantolol (the hydrochloride salt) has pharmacokinetic properties that are clinically advantageous. Bevantolol is well absorbed orally (> 70%); and the systemic bioavailability is 60%. Peak plasma concentrations are achieved 1 to 2 hours following an oral dose. Elimination is first-order with an average elimination half-life of 1.5 hours. Bevantolol exhibits linear pharmacokinetics within the therapeutic range (100 to 400 mg) with no change in half-life with chronic dosing. These properties result in predictable plasma levels and predictable drug response.
ACCESSION #
16365102

 

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