TITLE

PATHOGENESIS AND CLINICAL SIGNIFICANCE OF ' CONSTITUTIONAL HYPERTENSION

AUTHOR(S)
Bauer, Julius
PUB. DATE
December 1960
SOURCE
Angiology;Dec1960 Part 1, Vol. 11 Issue 6, p499
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. The term essential hypertension should be replaced by constitutional hypertension which designates the genetic factor in its etiology. Constitutional hypertension is not a disease in its own right, but is a predisposing condition to diseases of the heart and blood vessels. 2. The fundamental anomaly of constitutional hypertension is a deficient homeostasis of blood pressure which secures a steady maintenance of blood pressure by equalizing continuous daily variations of �supplementary� blood pressure. 3. The homeostatic mechanism of blood pressure is guaranteed by the precise cooperation and interrelation of complex nervous and hormonal functions. Its perfection slowly deteriorates with advancing age and may be deficient as a constitutional trait. 4. Constitutional hypertension results from multifactorial (polygenic) heredity and belongs to the same category of �continuous variability� as does the heredity of stature, physiognomy, intelligence or physiologic longevity. 5. Protracted chronic emotional strain is not an etiologic factor of constitutional hypertension if the homeostatic mechanism of blood pressure is perfect. 6. Aging of arteries (�presbyosclerosis�) may modify the clinical picture of constitutional hypertension. This can best be recognized by lowering of the diastolic pressure and thereby increasing pulse pressure.
ACCESSION #
16365064

 

Related Articles

  • EVALUATION OF HYPERTENSION.  // Monthly Prescribing Reference;Sep2011, Vol. 27 Issue 9, p4 

    The article offers information related to hypertension, including its diagnostic workup, identifiable causes, and classification of blood pressure.

  • Fatores genéticos e variabilidade na pressão arterial. Uma breve revisão da literatura. Fermino, Rogério César; Seabra, André; Garganta, Rui; Maia, José António Ribeiro // Brazilian Journal of Kineanthropometry & Human Performance;2009, Vol. 11 Issue 3, p341 

    The article analyzes the information regarding the role of genetic factors for the variability of blood pressure levels. It mentions that a search was conducted in the Pubmed database and the following studies were chosen including studies on familial aggregation with heritability estimates,...

  • Blood Pressure Levels in Male Carriers of Arg82Cys in CD300LG. Støy, Julie; Grarup, Niels; Hørlyck, Arne; Ibsen, Liselotte; Rungby, Jørgen; Poulsen, Per Løgstrup; Brandslund, Ivan; Christensen, Cramer; Hansen, Torben; Pedersen, Oluf; Møller, Niels; Kampmann, Ulla // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    : The genetics of hypertension has been scrutinized in large-scale genome-wide association studies (GWAS) with a large number of common genetic variants identified, each exerting subtle effects on disease susceptibility. An amino acid polymorphism, p.Arg82Cys, in CD300LG was recently found to...

  • β2-Adrenergic receptor polymorphisms and treatment-induced regression of left ventricular hypertrophy in hypertension*. Iaccarino, Guido; Izzo, Raffaele; Trimarco, Valentina; Cipolletta, Ersilia; Lanni, Francesca; Sorriento, Daniela; Iovino, Gianni Luigi; Rozza, Francesco; De Luca, Nicola; Priante, Ornella; Di Renzo, Gianfranco; Trimarco, Bruno // Clinical Pharmacology & Therapeutics;Dec2006, Vol. 80 Issue 6, p633 

    Objectives: Although blood pressure is considered the major determinant of left ventricular hypertrophy in hypertension, genetic variability is increasingly being considered among the factors influencing this complication. β2-Adrenergic receptors (β2ARs) are up-regulated in hypertension...

  • GOSR2 Lys67Arg Is Associated With Hypertension in Whites. Meyer, Tamra E.; Shiffman, Dov; Morrison, Alanna C.; Rowland, Charles M.; Louie, Judy Z.; Bare, Lance A.; Ross, David A.; Arellano, Andre R.; Chasman, Daniel I.; Ridker, Paul M.; Pankow, James S.; Coresh, Josef; Malloy, Mary J.; Kane, John P.; Ellis, Stephen G.; Devlin, James J.; Boerwinkle, Eric // American Journal of Hypertension;Feb2009, Vol. 22 Issue 2, p163 

    BackgroundHypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP...

  • Blood pressure and mortality: using offspring blood pressure as an instrument for own blood pressure in the HUNT study. Wade, Kaitlin H; Carslake, David; Timpson, Nicholas J; Davey Smith, George; Ivar Nilsen, Tom; Romundstad, Pål // Scientific Reports;7/24/2015, p12399 

    Given that observational associations may be inaccurate, we used offspring blood pressure (BP) to provide alternative estimates of the associations between own BP and mortality. Observational associations between BP and mortality, estimated as hazard ratios (HRs) from Cox regression, were...

  • Hypertension. Jenkins, Gill // Update;May2007, Vol. 74 Issue 5, p43 

    The article presents information on various aspects of hypertension. It states that many epidemiological evidences support that a stage of high-normal blood pressure or pre-hypertension would evolve into hypertension with ageing. It states that regular exercise would reduce blood pressure (BP)...

  • Blood Pressure and Risk of Death from External Causes among Men Screened for the Multiple Risk Factor Intervention Trial. Paul D. Terry; Jerome L. Abramson; James D. Neaton // American Journal of Epidemiology;Feb2007, Vol. 165 Issue 3, p294 

    A few epidemiologic studies have shown an increased risk of death from external causes among men with hypertension. Previous studies were limited by small numbers of events, however, and none assessed the association of blood pressure with specific types of “accidental” death. The...

  • Importance of quantitative genetic variations in the etiology of hypertension. Smithies, Oliver; Kim, Hyung-Suk; Takahashi, Nobuyuki; Edgell, Marshall H. // Kidney International;Dec2000, Vol. 58 Issue 6, p2265 

    Importance of quantitative genetic variations in the etiology of hypertension. Recent progress has been remarkable in identifying mutations which cause diseases (mostly uncommon) that are inherited simply. Unfortunately, the common diseases of humankind with a strong genetic component, such as...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics