TITLE

Procainamide, N--Acetylprocainamide, Antinuclear Antibody and Systemic Lupus Erythomatosus

AUTHOR(S)
Reidenberg, Marcus M.; Drayer, Dennis E.
PUB. DATE
December 1986
SOURCE
Angiology;Dec1986 Part 2, Vol. 37 Issue 12, p968
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Long-term therapy with procainamide (PA) leads to the systemic lupus erythematosus syndrome (SLE) in about 30% of patients and 80% develop antinuclear antibodies. Acetylation of procainamide results in the formation of N-acetylprocainamide (NAPA) the propensity of which to induce SLE and to increase antinuclear antibodies is negligible while its antiarrhythmic properties remain. Slow acetylators of PA have a greater tendency to induce SLE consistent with the observation that it is the level of PA that is responsible for the observed immunologically-mediated side effects of the compound. This is also suggested by the remission of PA-induced SLE when PA is replaced with NAPA for the control of cardiac arrhythmias. Thus, NAPA, compared to the parent compound, has little tendency to induce SLE.
ACCESSION #
16364883

 

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