TITLE

PERIPHERAL VASCULAR CIRCULATION IN PATIENTS WITH RHEUMATOID ARTHRITIS INFLUENCE OF PAPAVERINE

AUTHOR(S)
Batterman, Robert C.; Jensen, Gary; Jensen, Lynette
PUB. DATE
October 1970
SOURCE
Angiology;Oct1970, Vol. 21 Issue 9, p612
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
(1) Utilizing the method of plethysmography without venous occlusion and by determination of the pulse area by computer analysis, the circulatory status of patients with rheumatoid arthritis was found decreased by statistical standards (p < .001) as compared with patients with osteoarthritis and normal no-arthritic subjects. (2) The vascular response following administration orally of papaverine is also significantly different (p < .001) for rheumatoid patients. (3) The vasodilating effects of papaverine are noted unequivocally in patients with rheumatoid arthritis who have functional vasospams. (4) Venous pathophysiology may explain the different digital circulation of patients with rheumatoid arthritis as well as the different response to papaverine. (5) Chronic administration orally of papaverine in selected patients with rheumatoid arthritis resulted in a significant increase in the digital circulation of 9 of the 13 subjects. Therapeutic benefits were noted but the subjective improvements requires further evaluation by "blind" controlled studies.
ACCESSION #
16364499

 

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