TITLE

Failure of Thrombin-Antithrombin III Complexes in the Diagnosis of Deep Vein Thrombosis

AUTHOR(S)
Cogo, Alberto; Lensing, Anthonie; Prandoni, Paolo; Canova, Giuseppe; de Toni, Renzo; Cuppini, Stefano; Ruol, Arturo
PUB. DATE
December 1992
SOURCE
Angiology;Dec1992, Vol. 43 Issue 12, p975
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Plasma thrombin-antithrombin III (T-AT) complexes are reputed to be an indirect manifestation of thrombin generation, and a role for their determination in the diagnosis of deep vein thrombosis (DVT) has been advocated. In order to evaluate the accuracy of T-AT complexes assay for DVT diagnosis, in 166 consecutive outpatients with clinical suspicion of the disease, plasma concentration of T-AT complexes was measured immediately before venography by means of an enzyme-linked immunosorbent assay kit. The result of the T-AT complexes assay was elevated in 29 of the 48 patients with DVT (sensitivity, 60%). The T-AT complexes levels were within the normal range in 104 of the 118 patients with normal venograms (specificity, 88%). The positive and the negative predictive value were 67% and 85%, respectively. The authors conclude that the T-AT complexes assay is of little value for the diagnosis of DVT in outpatients.
ACCESSION #
16361613

 

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