Chandra, Ramesh; Abraham, Jacob
April 1973
Angiology;Apr1973, Vol. 24 Issue 4, p199
Academic Journal
A preliminary study of in Vitro and in Vivo changes in the various factors of coagulation by 50% Hypaque in man is reported. Significant inhibition of all the stages of clotting and increased fibrinolytic activity were demonstrated by various special laboratory tests. Persistence of such coagulation defects after pancerebral angiography was observed even after 24 hours. It is suggested that binding of factors of coagulation with the contrast medium may be the underlying cause. A gross reduction of Serum Calcium in an in vitro Blood-Hypaque mixture of a blood sample drawn from a patient prior to angiography, compared with a venous blood sample may serve as an index for possible adverse reaction. It indicates not only the extent of alteration in Calcium level but also reflects indirectly the reduction in serum protein and the factors of coagulation.


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