Sacks, Alvin H.
May 1975
Angiology;May1975, Vol. 26 Issue 5, p385
Academic Journal
It is postulated that the increased compressive stress in the arterial wall associated with the elevated arterial pressures of hypertension produce a flattening of the vasa vasorum which compromises vasa flow, hereby producing local hypoxia and accelerating the sclerotic process. Large scale simulation studies were carried out in which the flow rates and pressure drops through a partially collapsed vasa were measured as a function of radial compressive stress. The results indicate that (1) substantial reductions in vasa patency may be expected for physiologic elevations in arterial blood pressure, and (2) the reduction in vasa flow depends upon the stiffness of the arterial wall and would therefore be more significant in softer or younger arteries.


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