TITLE

Impact of Thromboischemic Reentry Mechanism on Coronary Thrombosis and Microembolism in Acute Myocardial Infarction

AUTHOR(S)
Gasser, Robert N. A.; Dienstl, Franz; Henn, Rainer
PUB. DATE
July 1987
SOURCE
Angiology;Jul1987, Vol. 38 Issue 7, p562
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
It has been suggested that the thromboischemic reentry mechanism (TRM) is responsible for washing platelet aggregates out of the coronary vessels during the early phase of acute myocardial infarction (AMI). This might account for the observation of Schwartz, who reported the presence of multiple microthrombi in the subendocardial blood vessels following AMI but found only a few thrombotic occlusions in the main coronary arteries. This washing-out of the vessel (due to reperfusion waves) intermittently releases myoglobin into the serum and is responsible for the ‘staccato phenomenon.’ We examined a group of 177 patients with a mean age of 66.1 years, whose sudden death was definitely of cardiac origin. Infarction was confirmed in 84.7% of the subjects (fresh infarct: 23.7%; fresh infarct with scarring: 25.9%; scarring alone: 35.0%; no change in myocardium: 15.2%). In other words, 49.7% of all postmortem subjects (88 cases) showed fresh infarction. Opening the coronary arteries longitudinally revealed only 7 thrombi in these 88 cases, i.e., 7.9% of all fresh infarcts. These observations confirm those of Roberts (8.5%) and Friedmann (4%).
ACCESSION #
16359716

 

Related Articles

  • Coronary Angioscopy Revealing Ruptured Plaque and Thrombus Causing Acute Anterior Myocardial Infarction With a Subsequent Acute Inferior Myocardial Infarction -- A Case Report. Yuji Okuyama; Masaya Usami; Yasunori Ueda; lomohito Ohtani; Vasuharu Takeda; Isamu Mizote; Atsushi Hirayama; Kazuhisa Kodama // International Journal of Angiology (Springer Science & Business ;Winter2005, Vol. 14 Issue 1, p34 

    We report a unique case that suggests that a thrombotic coronary occlusion was caused by local plaque rupture in the left anterior descending coronary artery (LAD), with subsequent thrombotic occlusion in the right coronary artery (RCA), and presented with simultaneous double coronary artery...

  • Progress in the Field of GPIIb/IIIa Antagonists. Hanson, Julien; De Leval, Xavier; David, Jean-Louis; Supuran, Claudiu; Pirotte, Bernard; Dogn�, Jean-Michel // Current Medicinal Chemistry - Cardiovascular & Hematological Age;Jun2004, Vol. 2 Issue 2, p157 

    Platelet aggregation plays an important role in pathological situations such as myocardial infarction, unstable angina, peripheral artery disease, and stroke. Thus, pharmacological agents that specifically inhibit platelet aggregation are of great interest in the treatment and prevention of...

  • Significance of αIIbβ3 in Subacute Stent Thrombosis After Percutaneous Coronary Invention. Inami, Norihito; Nomura, Shosaku; Kajiura, Takayuki; Yamada, Kohichi; Nakamori, Hisato; Takahashi, Nobuyuki; Tsuda, Nobuyuki; Fukuhara, Shirou; Iwasaka, Toshiji // Clinical & Applied Thrombosis/Hemostasis;Oct2005, Vol. 11 Issue 4, p455 

    Soluble P-selectin and whole blood aggregation (WBA) were measured after percutaneous coronary intervention in patients who then received antiplatelet therapy. One had subacute thrombosis on day 7. This patient's WBA exhibited time-dependent enhancement. In addition, the accentuation of WBA on...

  • Calcium-dependent platelet aggregation through the interaction between phosphatidylserine and LOX-1. Otsui, Kazunori; Kakutani, Makoto; Yuasa, Koji; Nakano, Atushi; Hu, Chang-Ping; Kakino, Akemi; Sato, Yuko; Fujita, Yoshiko; Kawase, Yosuke; Jishage, Kou-ichi; Suzuki, Hiroshi; Mehta, Jawahar L.; Yokoyama, Mitsuhiro; Hirata, Ken-ichi; Inoue, Nobutaka; Sawamura, Tatsuya // Cardiovascular Research;Dec2010, Vol. 88 Issue 3, p547 

    Aims Platelet aggregation at the injured surface of blood vessels plays a crucial role in arterial thrombosis. Platelet aggregation in plasma has been analysed in the presence of calcium chelator to avoid coagulation. Here, we describe a novel mechanism of platelet aggregation that involves...

  • A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization. Morice, Marie-Claude; Serruys, Patrick W.; Sousa, J. Eduardo; Fajadet, Jean; Ban Hayashi, Ernesto; Perin, Marco; Colombo, Antonio; Schuler, G.; Barragan, Paul; Guagliumi, Giulio; Molnàr, Ferenc; Falotico, Robert // New England Journal of Medicine;6/6/2002, Vol. 346 Issue 23, p1773 

    Background: The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) inhibits the proliferation of lymphocytes and smooth-muscle cells, we compared a sirolimus-eluting stent with a...

  • Hereditary thrombophilia (factor V R2-mutation) as a contributing factor in premature myocardial infarction associated with pregnancy. Kayıkçıoğlu, Meral; Yavuzgil, Oğuz; Eroğlu, Zuhal; Onay, Hüseyin; Ergenoğlu, Mete; Can, Levent // Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Nov2014, Vol. 14 Issue 7, p652 

    The article presents case studies of a 29-year-old pregnant woman with myocardial infarction (MI) and a 41-year-old woman with acute MI. It discussed include development of MI in pregnant women, mentions that increase in concentration of fibrinogen, coagulation factors, and platelet adhesiveness...

  • Magnesium stents show biodegradability in four months.  // Cardiovascular Device Update;Jun2007, Vol. 13 Issue 6, p11 

    The article reports on a study conducted by Professor Raimund Erbel, Department of Cardiology, West German Heart Centre in Essen, Germany and colleagues which concluded that biodegradable magnesium stents have been developed to treat blockages in coronary arteries which can degrade within four...

  • Myocardial Infarction Complicating Postsplenectomy Thrombocytosis, with Early Left Ventricular Mural Thrombus Formation and Cerebral Embolism--A Case Report. Yau Ting Tai; Yuk Ling Yu; Chu Pak Lau; Ping Ching Fong // Angiology;Jan1993 Supplement, Vol. 44, p73 

    Thrombocytosis is a rare cause of ischemic cardiovascular and cerebrovascular events in patients with intrinsically normal coronary and cerebral vasculature. This report details the occurrence of inferior wall myocardial infarction (MI) consequent upon postsplenectomy thrombocytosis in a...

  • thrombosis. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p742 

    An encyclopedia entry for "thrombosis" is presented. Thrombosis pertains to the formation of thrombus, or blood clot, in an undamaged blood vessel. The formation of a blood clot within an artery supplying the heart muscle is the usual cause of myocardial infarction or heart attack. Diagnosis of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics